Avatrombopag • ChemWhat中文网 | 凯望化学与生物数据库

Avatrombopag Nitroso Impurity 1 CAS#: N/A

By great_watson-int, 7th July 2024

Identification	Physical Data	Spectra
Route of Synthesis (ROS)	Safety and Hazards	Other Data

Identification

Physical Data

Appearance	No data available
Solubility	No data available
Flash Point	No data available
Refractive index	No data available
Sensitivity	No data available
Melting Point	No data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

No data available

Other Data

HS Code	382290
Storage	At room temperature and away from light
Related Chemicals

Use Pattern

Avatrombopag Nitroso Impurity 1 is chemically 1-(3-Chloro-5-((4-(4-chlorothiophen-2-yl)-5-(4-nitrosopiperazin-1-yl)thiazol-2-yl)carbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid. Avatrombopag Nitroso Impurity 1 is supplied with detailed characterization data compliant with regulatory guideline. Avatrombopag Nitroso Impurity 1 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Avatrombopag. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

Avatrombopag Impurity 3 CAS#: 81216-84-4

By great_watson-int, 7th July 2024

Identification	Physical Data	Spectra
Route of Synthesis (ROS)	Safety and Hazards	Other Data

Identification

Physical Data

Appearance	No data available
Solubility	No data available
Flash Point	No data available
Refractive index	No data available
Sensitivity	No data available
Melting Point	No data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

No data available

Other Data

HS Code	382290
Storage	At room temperature and away from light
Related Chemicals

Use Pattern

Avatrombopag Impurity 3 is chemically 5-Bromo-4-(thiophen-2-yl)thiazol-2-amine. Avatrombopag Impurity 3 is supplied with detailed characterization data compliant with regulatory guideline. Avatrombopag Impurity 3 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Avatrombopag. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

Avatrombopag Maleate CAS#: 677007-74-8

By great_watson-int, 7th July 2024

Identification	Physical Data	Spectra
Route of Synthesis (ROS)	Safety and Hazards	Other Data

Identification

Physical Data

Appearance	No data available
Solubility	No data available
Flash Point	No data available
Refractive index	No data available
Sensitivity	No data available
Melting Point	No data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

No data available

Other Data

HS Code	382290
Storage	At room temperature and away from light
Related Chemicals	570406-98-3 (free base)

Use Pattern

Avatrombopag Maleate is chemically 1-(3-Chloro-5-((4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)carbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid compound with maleic acid (1:1). Avatrombopag Maleate is supplied with detailed characterization data compliant with regulatory guideline. Avatrombopag Maleate can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Avatrombopag. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

Avatrombopag Impurity 4 CAS#: 1268118-96-2

By great_watson-int, 7th July 2024

Identification	Physical Data	Spectra
Route of Synthesis (ROS)	Safety and Hazards	Other Data

Identification

Physical Data

Appearance	No data available
Solubility	No data available
Flash Point	No data available
Refractive index	No data available
Sensitivity	No data available
Melting Point	No data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

No data available

Other Data

HS Code	382290
Storage	At room temperature and away from light
Related Chemicals

Use Pattern

Avatrombopag Impurity 4 is chemically 5-Bromo-4-(5-chlorothiophen-2-yl)thiazol-2-amine. Avatrombopag Impurity 4 is supplied with detailed characterization data compliant with regulatory guideline. Avatrombopag Impurity 4 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Avatrombopag. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

Avatrombopag Impurity 1 CAS#: 2401867-89-6

By great_watson-int, 7th July 2024

Identification	Physical Data	Spectra
Route of Synthesis (ROS)	Safety and Hazards	Other Data

Identification

Physical Data

Appearance	No data available
Solubility	No data available
Flash Point	No data available
Refractive index	No data available
Sensitivity	No data available
Melting Point	No data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

No data available

Other Data

HS Code	382290
Storage	At room temperature and away from light
Related Chemicals

Use Pattern

Avatrombopag Impurity 1 is chemically 5-Bromo-4-(5-bromo-4-chlorothiophen-2-yl)thiazol-2-amine. Avatrombopag Impurity 1 is supplied with detailed characterization data compliant with regulatory guideline. Avatrombopag Impurity 1 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Avatrombopag. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

Avatrombopag Impurity 2 CAS#: 1534575-19-3

By great_watson-int, 7th July 2024

Identification	Physical Data	Spectra
Route of Synthesis (ROS)	Safety and Hazards	Other Data

Identification

Physical Data

Appearance	No data available
Solubility	No data available
Flash Point	No data available
Refractive index	No data available
Sensitivity	No data available
Melting Point	No data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

No data available

Other Data

HS Code	382290
Storage	At room temperature and away from light
Related Chemicals

Use Pattern

Avatrombopag Impurity 2 is chemically 4-(5-Bromo-4-chlorothiophen-2-yl)thiazol-2-amine. Avatrombopag Impurity 2 is supplied with detailed characterization data compliant with regulatory guideline. Avatrombopag Impurity 2 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Avatrombopag. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

Avatrombopag Diamide Impurity CAS#: N/A

By great_watson-int, 7th July 2024

Identification	Physical Data	Spectra
Route of Synthesis (ROS)	Safety and Hazards	Other Data

Identification

Physical Data

Appearance	No data available
Solubility	No data available
Flash Point	No data available
Refractive index	No data available
Sensitivity	No data available
Melting Point	No data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

No data available

Other Data

HS Code	382290
Storage	At room temperature and away from light
Related Chemicals

Use Pattern

Avatrombopag Diamide Impurity is chemically 5-Chloro-N-(4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)-6-(4-((4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)carbamoyl)piperidin-1-yl)nicotinamide. Avatrombopag Diamide Impurity is supplied with detailed characterization data compliant with regulatory guideline. Avatrombopag Diamide Impurity can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Avatrombopag. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

Avatrombopag Bromo Acid Impurity CAS#: N/A

By great_watson-int, 7th July 2024

Identification	Physical Data	Spectra
Route of Synthesis (ROS)	Safety and Hazards	Other Data

Identification

Physical Data

Appearance	No data available
Solubility	No data available
Flash Point	No data available
Refractive index	No data available
Sensitivity	No data available
Melting Point	No data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

No data available

Other Data

HS Code	382290
Storage	At room temperature and away from light
Related Chemicals

Use Pattern

Avatrombopag Bromo Acid Impurity is chemically 1-(5-((4-(5-Bromo-4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)carbamoyl)-3-chloropyridin-2-yl)piperidine-4-carboxylic acid. Avatrombopag Bromo Acid Impurity is supplied with detailed characterization data compliant with regulatory guideline. Avatrombopag Bromo Acid Impurity can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Avatrombopag. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

Avatrombopag d8 CAS#: N/A

By great_watson-int, 7th July 2024

Identification	Physical Data	Spectra
Route of Synthesis (ROS)	Safety and Hazards	Other Data

Identification

Physical Data

Appearance	No data available
Solubility	No data available
Flash Point	No data available
Refractive index	No data available
Sensitivity	No data available
Melting Point	No data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

No data available

Other Data

HS Code	382290
Storage	At room temperature and away from light
Related Chemicals	570406-98-3 (Unlabelled)

Use Pattern

Avatrombopag d8 is chemically 1-(3-chloro-5-((4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl-2,2,3,3,5,5,6,6-d8)thiazol-2-yl)carbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid. Avatrombopag d8 is supplied with detailed characterization data compliant with regulatory guideline. Avatrombopag d8 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Avatrombopag. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

Avatrombopag Di Acid Impurity CAS#: 958457-83-5

By great_watson-int, 7th July 2024

Identification	Physical Data	Spectra
Route of Synthesis (ROS)	Safety and Hazards	Other Data

Identification

Physical Data

Appearance	No data available
Solubility	No data available
Flash Point	No data available
Refractive index	No data available
Sensitivity	No data available
Melting Point	No data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

No data available

Other Data

HS Code	382290
Storage	At room temperature and away from light
Related Chemicals

Use Pattern

Avatrombopag Di Acid Impurity is chemically 6-(4-Carboxypiperidin-1-yl)-5-chloronicotinic acid. Avatrombopag Di Acid Impurity is supplied with detailed characterization data compliant with regulatory guideline. Avatrombopag Di Acid Impurity can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Avatrombopag. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

英文名	Avatrombopag Nitroso Impurity 1
分子结构
CAS编号	N/A
EINECS Number
MDL Number
Beilstein Registry Number
别名	1-(3-Chloro-5-((4-(4-chlorothiophen-2-yl)-5-(4-nitrosopiperazin-1-yl)thiazol-2-yl)carbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid
分子式	C23H23Cl2N7O4S2
分子量	596.5
InChI
InChI Key
Canonical SMILES	O=C(C1CCN(C2=NC=C(C(NC3=NC(C4=CC(Cl)=CS4)=C(N5CCN(N=O)CC5)S3)=O)C=C2Cl)CC1)O

英文名	Avatrombopag Impurity 3
分子结构
CAS编号	81216-84-4
EINECS Number
MDL Number
Beilstein Registry Number
别名	5-Bromo-4-(thiophen-2-yl)thiazol-2-amine
分子式	C7H5BrN2S2
分子量	261.2
InChI
InChI Key
Canonical SMILES	NC1=NC(C2=CC=CS2)=C(Br)S1

英文名	Avatrombopag Maleate
分子结构
CAS编号	677007-74-8
EINECS Number
MDL Number
Beilstein Registry Number
别名	1-(3-Chloro-5-((4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)carbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid compound with maleic acid (1:1)
分子式	C29H34Cl2N6O3S2 : C4H4O4
分子量	649.7 : 116.1
InChI
InChI Key
Canonical SMILES	O=C(C1=CN=C(N2CCC(C(O)=O)CC2)C(Cl)=C1)NC3=NC(C4=CC(Cl)=CS4)=C(N5CCN(C6CCCCC6)CC5)S3.OC(/C=CC(O)=O)=O

英文名	Avatrombopag Impurity 4
分子结构
CAS编号	1268118-96-2
EINECS Number
MDL Number
Beilstein Registry Number
别名	5-Bromo-4-(5-chlorothiophen-2-yl)thiazol-2-amine
分子式	C7H4BrClN2S2
分子量	295.6
InChI
InChI Key
Canonical SMILES	NC1=NC(C2=CC=C(Cl)S2)=C(Br)S1

英文名	Avatrombopag Impurity 1
分子结构
CAS编号	2401867-89-6
EINECS Number
MDL Number
Beilstein Registry Number
别名	5-Bromo-4-(5-bromo-4-chlorothiophen-2-yl)thiazol-2-amine
分子式	C7H3Br2ClN2S2
分子量	374.5
InChI
InChI Key
Canonical SMILES	NC1=NC(C2=CC(Cl)=C(Br)S2)=C(Br)S1

英文名	Avatrombopag Impurity 2
分子结构
CAS编号	1534575-19-3
EINECS Number
MDL Number
Beilstein Registry Number
别名	4-(5-Bromo-4-chlorothiophen-2-yl)thiazol-2-amine
分子式	C7H4BrClN2S2
分子量	295.6
InChI
InChI Key
Canonical SMILES	NC1=NC(C2=CC(Cl)=C(Br)S2)=CS1

英文名	Avatrombopag Diamide Impurity
分子结构
CAS编号	N/A
EINECS Number
MDL Number
Beilstein Registry Number
别名	5-Chloro-N-(4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)-6-(4-((4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)carbamoyl)piperidin-1-yl)nicotinamide
分子式	C46H55Cl3N10O2S4
分子量	1014.6
InChI
InChI Key
Canonical SMILES	O=C(C1=CN=C(N2CCC(C(NC3=NC(C4=CC(Cl)=CS4)=C(N5CCN(C6CCCCC6)CC5)S3)=O)CC2)C(Cl)=C1)NC7=NC(C8=CC(Cl)=CS8)=C(N9CCN(C%10CCCCC%10)CC9)S7

英文名	Avatrombopag Bromo Acid Impurity
分子结构
CAS编号	N/A
EINECS Number
MDL Number
Beilstein Registry Number
别名	1-(5-((4-(5-Bromo-4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)carbamoyl)-3-chloropyridin-2-yl)piperidine-4-carboxylic acid
分子式	C29H33BrCl2N6O3S2
分子量	728.5
InChI
InChI Key
Canonical SMILES	O=C(C1=CN=C(N2CCC(C(O)=O)CC2)C(Cl)=C1)NC3=NC(C4=CC(Cl)=C(Br)S4)=C(N5CCN(C6CCCCC6)CC5)S3

英文名	Avatrombopag d8
分子结构
CAS编号	N/A
EINECS Number
MDL Number
Beilstein Registry Number
别名	1-(3-chloro-5-((4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl-2,2,3,3,5,5,6,6-d8)thiazol-2-yl)carbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid
分子式	C29H26D8Cl2N6O3S2
分子量	657.7
InChI
InChI Key
Canonical SMILES	O=C(C1=CN=C(N2CCC(C(O)=O)CC2)C(Cl)=C1)NC3=NC(C4=CC(Cl)=CS4)=C(N5C([2H])([2H])C([2H])([2H])N(C6CCCCC6)C([2H])([2H])C5([2H])[2H])S3

英文名	Avatrombopag Di Acid Impurity
分子结构
CAS编号	958457-83-5
EINECS Number
MDL Number
Beilstein Registry Number
别名	6-(4-Carboxypiperidin-1-yl)-5-chloronicotinic acid
分子式	C12H13ClN2O4
分子量	284.7
InChI
InChI Key
Canonical SMILES	ClC1=CC(C(O)=O)=CN=C1N2CCC(C(O)=O)CC2