m7GpppNm CAS#:

By Janice Zhang,
Structure of m7GpppNm
IdentificationPhysical DataSpectra
Route of Synthesis (ROS)Safety and HazardsOther Data

Identification

英文名m7GpppNm
IUPAC Namecap 1
分子结构Structure of m7GpppNm
CAS编号 No data available
EINECS NumberNo data available
MDL NumberNo data available
Beilstein Registry NumberNo data available
别名cap 0
分子式No data available
分子量No data available
InChINo data available
InChI KeyNo data available
Canonical SMILESNo data available
Patent Information
No data available

Physical Data

AppearanceWhite powder
SolubilityNo data available
Flash PointNo data available
Refractive indexNo data available
SensitivityNo data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

GHS Hazard StatementsNot Classified
For more detailed information, please visit ECHA C&L website
Source: European Chemicals Agency (ECHA)
License Note: Use of the information, documents and data from the ECHA website is subject to the terms and conditions of this Legal Notice, and subject to other binding limitations provided for under applicable law, the information, documents and data made available on the ECHA website may be reproduced, distributed and/or used, totally or in part, for non-commercial purposes provided that ECHA is acknowledged as the source: “Source: European Chemicals Agency, http://echa.europa.eu/”. Such acknowledgement must be included in each copy of the material. ECHA permits and encourages organisations and individuals to create links to the ECHA website under the following cumulative conditions: Links can only be made to webpages that provide a link to the Legal Notice page.
License URL: https://echa.europa.eu/web/guest/legal-notice
Record Name: (1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino-carbenium hexafluorophosphate
URL: https://echa.europa.eu/information-on-chemicals/cl-inventory-database/-/discli/details/213446
Description: The information provided here is aggregated from the “Notified classification and labelling” from ECHA’s C&L Inventory. Read more: https://echa.europa.eu/information-on-chemicals/cl-inventory-database

Other Data

TransportationNONH for all modes of transport
Under the room temperature and away from light
HS CodeNo data available
StorageUnder the room temperature and away from light
Shelf Life1 year
Market PriceUSD

Druglikeness

Use Pattern
In the cell, the cap 0 structure is essential for efficient translation of the mRNA that carries the cap.
An additional methylation on the 2′O position of the initiating nucleotide generates Cap 1, or refers to as m7GpppNm, where Nm denotes any nucleotide with a 2′O methylation.
Cap 1 or m7GpppNm has been shown to be important in evading the cellular innate immune response in vivo.
The third generation of cap structure, co-transcriptional capping, capping efficiency 95%

m7Gppp CAS#:

By Janice Zhang,
Structure of m7Gppp
IdentificationPhysical DataSpectra
Route of Synthesis (ROS)Safety and HazardsOther Data

Identification

英文名m7Gppp
IUPAC Namecap 0
分子结构Structure of m7Gppp
CAS编号 No data available
EINECS NumberNo data available
MDL NumberNo data available
Beilstein Registry NumberNo data available
别名cap 0
分子式No data available
分子量No data available
InChINo data available
InChI KeyNo data available
Canonical SMILESNo data available
Patent Information
No data available

Physical Data

AppearanceWhite powder
SolubilityNo data available
Flash PointNo data available
Refractive indexNo data available
SensitivityNo data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

GHS Hazard StatementsNot Classified
For more detailed information, please visit ECHA C&L website
Source: European Chemicals Agency (ECHA)
License Note: Use of the information, documents and data from the ECHA website is subject to the terms and conditions of this Legal Notice, and subject to other binding limitations provided for under applicable law, the information, documents and data made available on the ECHA website may be reproduced, distributed and/or used, totally or in part, for non-commercial purposes provided that ECHA is acknowledged as the source: “Source: European Chemicals Agency, http://echa.europa.eu/”. Such acknowledgement must be included in each copy of the material. ECHA permits and encourages organisations and individuals to create links to the ECHA website under the following cumulative conditions: Links can only be made to webpages that provide a link to the Legal Notice page.
License URL: https://echa.europa.eu/web/guest/legal-notice
Record Name: (1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino-carbenium hexafluorophosphate
URL: https://echa.europa.eu/information-on-chemicals/cl-inventory-database/-/discli/details/213446
Description: The information provided here is aggregated from the “Notified classification and labelling” from ECHA’s C&L Inventory. Read more: https://echa.europa.eu/information-on-chemicals/cl-inventory-database

Other Data

TransportationNONH for all modes of transport
Under the room temperature and away from light
HS CodeNo data available
StorageUnder the room temperature and away from light
Shelf Life1 year
Market PriceUSD

Druglikeness

Use Pattern
m7Gppp or Cap 0 is a N7-methyl guanosine connected to the 5′ nucleotide through a 5′ to 5′ triphosphate linkage, typically refers to as m7G cap or m7Gppp- in the literature.
In the cell, the cap 0 structure is essential for efficient translation of the mRNA that carries the cap.
The third generation of cap structure, co-transcriptional capping, capping efficiency 95%

ARCA Cap Analog CAS#: 400806-46-4

By Janice Zhang,
Structure of ARCA Cap Analog CAS 400806-46-4
IdentificationPhysical DataSpectra
Route of Synthesis (ROS)Safety and HazardsOther Data

Identification

英文名ARCA Cap Analog
IUPAC Namem27,3’OG[5′]ppp[5′]G
分子结构Structure of ARCA Cap Analog CAS 400806-46-4
CAS编号 400806-46-4
EINECS NumberNo data available
MDL NumberNo data available
Beilstein Registry NumberNo data available
别名m27,3’OG[5′]ppp[5′]G
分子式C22H31N10O18P3
分子量816.466
InChINo data available
InChI KeyAIRSQUYUYJSIIM-XPWFQUROSA-N
Canonical SMILESNo data available
Patent Information
No data available

Physical Data

AppearanceWhite powder
SolubilityNo data available
Flash PointNo data available
Refractive indexNo data available
SensitivityNo data available

Spectra

No data available

Route of Synthesis (ROS)

Route of Synthesis (ROS) of ARCA Cap Analog CAS 400806-46-4
Route of Synthesis (ROS) of ARCA Cap Analog CAS 400806-46-4
ConditionsYield
With zinc(II) chloride In N,N-dimethyl-formamide at 20℃; for 6h;70%

Safety and Hazards

GHS Hazard StatementsNot Classified
For more detailed information, please visit ECHA C&L website
Source: European Chemicals Agency (ECHA)
License Note: Use of the information, documents and data from the ECHA website is subject to the terms and conditions of this Legal Notice, and subject to other binding limitations provided for under applicable law, the information, documents and data made available on the ECHA website may be reproduced, distributed and/or used, totally or in part, for non-commercial purposes provided that ECHA is acknowledged as the source: “Source: European Chemicals Agency, http://echa.europa.eu/”. Such acknowledgement must be included in each copy of the material. ECHA permits and encourages organisations and individuals to create links to the ECHA website under the following cumulative conditions: Links can only be made to webpages that provide a link to the Legal Notice page.
License URL: https://echa.europa.eu/web/guest/legal-notice
Record Name: (1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino-carbenium hexafluorophosphate
URL: https://echa.europa.eu/information-on-chemicals/cl-inventory-database/-/discli/details/213446
Description: The information provided here is aggregated from the “Notified classification and labelling” from ECHA’s C&L Inventory. Read more: https://echa.europa.eu/information-on-chemicals/cl-inventory-database

Other Data

TransportationNONH for all modes of transport
Under the room temperature and away from light
HS CodeNo data available
StorageUnder the room temperature and away from light
Shelf Life1 year
Market PriceUSD

Druglikeness

Lipinski rules component
分子量816.466
logP-6.173
HBA27
HBD9
Matching Lipinski Rules1
Veber rules component
Polar Surface Area (PSA)431.05
Rotatable Bond (RotB)13
Matching Veber Rules0
Use Pattern
ARCA Cap Analog CAS#: 400806-46-4 as agent for generating capped mRNA stimulating translation