Dacomitinib • ChemWhat中文网 | 凯望化学与生物数据库

Dacomitinib-13C-d3 CAS#: N/A

By great_watson-int, 7th July 2024

Identification	Physical Data	Spectra
Route of Synthesis (ROS)	Safety and Hazards	Other Data

Identification

Physical Data

Appearance	No data available
Solubility	No data available
Flash Point	No data available
Refractive index	No data available
Sensitivity	No data available
Melting Point	No data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

No data available

Other Data

HS Code	382290
Storage	At room temperature and away from light
Related Chemicals

Use Pattern

Dacomitinib-13C-d3 is chemically (E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(methoxy-13C-d3)quinazolin-6-yl)-4-(piperidin-1-yl)but-2-enamide. Dacomitinib-13C-d3 is supplied with detailed characterization data compliant with regulatory guideline. Dacomitinib-13C-d3 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Dacomitinib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

Dacomitinib Impurity 3 CAS#: 2803478-54-6

By great_watson-int, 7th July 2024

Identification	Physical Data	Spectra
Route of Synthesis (ROS)	Safety and Hazards	Other Data

Identification

Physical Data

Appearance	No data available
Solubility	No data available
Flash Point	No data available
Refractive index	No data available
Sensitivity	No data available
Melting Point	No data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

No data available

Other Data

HS Code	382290
Storage	At room temperature and away from light
Related Chemicals

Use Pattern

Dacomitinib Impurity 3 is chemically N-(4-((4-Chloro-3-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(piperidin-1-yl)but-2-enamide. Dacomitinib Impurity 3 is supplied with detailed characterization data compliant with regulatory guideline. Dacomitinib Impurity 3 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Dacomitinib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

Dacomitinib Z-Isomer CAS#: N/A

By great_watson-int, 7th July 2024

Identification	Physical Data	Spectra
Route of Synthesis (ROS)	Safety and Hazards	Other Data

Identification

Physical Data

Appearance	No data available
Solubility	No data available
Flash Point	No data available
Refractive index	No data available
Sensitivity	No data available
Melting Point	No data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

No data available

Other Data

HS Code	382290
Storage	At room temperature and away from light
Related Chemicals

Use Pattern

Dacomitinib Z-Isomer is chemically (Z)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(piperidin-1-yl)but-2-enamide. Dacomitinib Z-Isomer is supplied with detailed characterization data compliant with regulatory guideline. Dacomitinib Z-Isomer can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Dacomitinib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

Dacomitinib Impurity 2 CAS#: 179552-75-1

By great_watson-int, 7th July 2024

Identification	Physical Data	Spectra
Route of Synthesis (ROS)	Safety and Hazards	Other Data

Identification

Physical Data

Appearance	No data available
Solubility	No data available
Flash Point	No data available
Refractive index	No data available
Sensitivity	No data available
Melting Point	No data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

No data available

Other Data

HS Code	382290
Storage	At room temperature and away from light
Related Chemicals

Use Pattern

Dacomitinib Impurity 2 is chemically N4-(3-chloro-4-fluorophenyl)-7-methoxyquinazoline-4,6-diamine. Dacomitinib Impurity 2 is supplied with detailed characterization data compliant with regulatory guideline. Dacomitinib Impurity 2 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Dacomitinib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

Dacomitinib Desmethyl Impurity CAS#: 2468202-15-3

By great_watson-int, 7th July 2024

Identification	Physical Data	Spectra
Route of Synthesis (ROS)	Safety and Hazards	Other Data

Identification

Physical Data

Appearance	No data available
Solubility	No data available
Flash Point	No data available
Refractive index	No data available
Sensitivity	No data available
Melting Point	No data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

No data available

Other Data

HS Code	382290
Storage	At room temperature and away from light
Related Chemicals

Use Pattern

Dacomitinib Desmethyl Impurity is chemically (E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-hydroxyquinazolin-6-yl)-4-(piperidin-1-yl)but-2-enamide. Dacomitinib Desmethyl Impurity is supplied with detailed characterization data compliant with regulatory guideline. Dacomitinib Desmethyl Impurity can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Dacomitinib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

Dacomitinib Nitroso Impurity CAS#: N/A

By great_watson-int, 6th July 2024

Identification	Physical Data	Spectra
Route of Synthesis (ROS)	Safety and Hazards	Other Data

Identification

Physical Data

Appearance	No data available
Solubility	No data available
Flash Point	No data available
Refractive index	No data available
Sensitivity	No data available
Melting Point	No data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

No data available

Other Data

HS Code	382290
Storage	At room temperature and away from light
Related Chemicals

Use Pattern

Dacomitinib Nitroso Impurity is chemically (E)-N-(4-((3-Chloro-4-fluorophenyl)(nitroso)amino)-7-methoxyquinazolin-6-yl)-4-(piperidin-1-yl)but-2-enamide. Dacomitinib Nitroso Impurity is supplied with detailed characterization data compliant with regulatory guideline. Dacomitinib Nitroso Impurity can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Dacomitinib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

Dacomitinib Impurity 1 CAS#: 2190490-31-2

By great_watson-int, 6th July 2024

Identification	Physical Data	Spectra
Route of Synthesis (ROS)	Safety and Hazards	Other Data

Identification

Physical Data

Appearance	No data available
Solubility	No data available
Flash Point	No data available
Refractive index	No data available
Sensitivity	No data available
Melting Point	No data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

No data available

Other Data

HS Code	382290
Storage	At room temperature and away from light
Related Chemicals

Use Pattern

Dacomitinib Impurity 1 is chemically 1-(4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-5-hydroxypyrrolidin-2-one. Dacomitinib Impurity 1 is supplied with detailed characterization data compliant with regulatory guideline. Dacomitinib Impurity 1 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Dacomitinib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

Dacomitinib d10 CAS#: N/A

By great_watson-int, 6th July 2024

Identification	Physical Data	Spectra
Route of Synthesis (ROS)	Safety and Hazards	Other Data

Identification

Physical Data

Appearance	No data available
Solubility	No data available
Flash Point	No data available
Refractive index	No data available
Sensitivity	No data available
Melting Point	No data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

No data available

Other Data

HS Code	382290
Storage	At room temperature and away from light
Related Chemicals

Use Pattern

Dacomitinib d10 is chemically (E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(piperidin-1-yl-d10)but-2-enamide. Dacomitinib d10 is supplied with detailed characterization data compliant with regulatory guideline. Dacomitinib d10 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Dacomitinib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

Dacomitinib CAS#: 1110813-31-4

By great_watson-int, 6th July 2024

Identification	Physical Data	Spectra
Route of Synthesis (ROS)	Safety and Hazards	Other Data

Identification

Physical Data

Appearance	No data available
Solubility	No data available
Flash Point	No data available
Refractive index	No data available
Sensitivity	No data available
Melting Point	No data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

No data available

Other Data

HS Code	382290
Storage	At room temperature and away from light
Related Chemicals

Use Pattern

Dacomitinib is chemically (E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(piperidin-1-yl)but-2-enamide. Dacomitinib is supplied with detailed characterization data compliant with regulatory guideline. Dacomitinib can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Dacomitinib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

Dacomitinib d5 CAS#: N/A

By great_watson-int, 6th July 2024

Identification	Physical Data	Spectra
Route of Synthesis (ROS)	Safety and Hazards	Other Data

Identification

Physical Data

Appearance	No data available
Solubility	No data available
Flash Point	No data available
Refractive index	No data available
Sensitivity	No data available
Melting Point	No data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

No data available

Other Data

HS Code	382290
Storage	At room temperature and away from light
Related Chemicals

Use Pattern

Dacomitinib d5 is chemically (E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(piperidin-1-yl-2,3,4,5,6-d5)but-2-enamide. Dacomitinib d5 is supplied with detailed characterization data compliant with regulatory guideline. Dacomitinib d5 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Dacomitinib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

英文名	Dacomitinib-13C-d3
分子结构
CAS编号	N/A
EINECS Number
MDL Number
Beilstein Registry Number
别名	(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(methoxy-13C-d3)quinazolin-6-yl)-4-(piperidin-1-yl)but-2-enamide
分子式	C2313CH22D3ClFN5O2
分子量	474.0
InChI
InChI Key
Canonical SMILES	ClC1=C(F)C=CC(NC2=NC=NC3=C2C=C(NC(/C=C/CN4CCCCC4)=O)C(O[13C]([2H])([2H])[2H])=C3)=C1

英文名	Dacomitinib Impurity 3
分子结构
CAS编号	2803478-54-6
EINECS Number
MDL Number
Beilstein Registry Number
别名	N-(4-((4-Chloro-3-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(piperidin-1-yl)but-2-enamide
分子式	C24H25ClFN5O2
分子量	469.9
InChI
InChI Key
Canonical SMILES	O=C(C=CCN1CCCCC1)NC2=CC(C(NC(C=C3)=CC(F)=C3Cl)=NC=N4)=C4C=C2OC

英文名	Dacomitinib Z-Isomer
分子结构
CAS编号	N/A
EINECS Number
MDL Number
Beilstein Registry Number
别名	(Z)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(piperidin-1-yl)but-2-enamide
分子式	C24H25ClFN5O2
分子量	469.9
InChI
InChI Key
Canonical SMILES	O=C(NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OC)/C=CCN4CCCCC4

英文名	Dacomitinib Impurity 2
分子结构
CAS编号	179552-75-1
EINECS Number
MDL Number
Beilstein Registry Number
别名	N4-(3-chloro-4-fluorophenyl)-7-methoxyquinazoline-4,6-diamine
分子式	C15H12ClFN4O
分子量	318.7
InChI
InChI Key
Canonical SMILES	NC1=CC(C(NC(C=C2)=CC(Cl)=C2F)=NC=N3)=C3C=C1OC

英文名	Dacomitinib Desmethyl Impurity
分子结构
CAS编号	2468202-15-3
EINECS Number
MDL Number
Beilstein Registry Number
别名	(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-hydroxyquinazolin-6-yl)-4-(piperidin-1-yl)but-2-enamide
分子式	C23H23ClFN5O2
分子量	455.9
InChI
InChI Key
Canonical SMILES	O=C(NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1O)/C=C/CN4CCCCC4

英文名	Dacomitinib Nitroso Impurity
分子结构
CAS编号	N/A
EINECS Number
MDL Number
Beilstein Registry Number
别名	(E)-N-(4-((3-Chloro-4-fluorophenyl)(nitroso)amino)-7-methoxyquinazolin-6-yl)-4-(piperidin-1-yl)but-2-enamide
分子式	C24H24ClFN6O3
分子量	498.9
InChI
InChI Key
Canonical SMILES	ClC1=C(F)C=CC(N(N=O)C2=NC=NC3=C2C=C(NC(/C=C/CN4CCCCC4)=O)C(OC)=C3)=C1

英文名	Dacomitinib Impurity 1
分子结构
CAS编号	2190490-31-2
EINECS Number
MDL Number
Beilstein Registry Number
别名	1-(4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-5-hydroxypyrrolidin-2-one
分子式	C19H16ClFN4O3
分子量	402.8
InChI
InChI Key
Canonical SMILES	FC(C=C1)=C(Cl)C=C1NC2=NC=NC3=CC(OC)=C(N4C(O)CCC4=O)C=C32

英文名	Dacomitinib d10
分子结构
CAS编号	N/A
EINECS Number
MDL Number
Beilstein Registry Number
别名	(E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(piperidin-1-yl-d10)but-2-enamide
分子式	C24H15D10ClFN5O2
分子量	480.0
InChI
InChI Key
Canonical SMILES	FC1=C(Cl)C=C(NC2=NC=NC3=C2C=C(NC(/C=C/CN4C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C4([2H])[2H])=O)C(OC)=C3)C=C1

英文名	Dacomitinib
分子结构
CAS编号	1110813-31-4
EINECS Number
MDL Number
Beilstein Registry Number
别名	(E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(piperidin-1-yl)but-2-enamide
分子式	C24H25ClFN5O2
分子量	470.0
InChI
InChI Key
Canonical SMILES	ClC1=C(F)C=CC(NC2=NC=NC3=C2C=C(NC(/C=C/CN4CCCCC4)=O)C(OC)=C3)=C1

英文名	Dacomitinib d5
分子结构
CAS编号	N/A
EINECS Number
MDL Number
Beilstein Registry Number
别名	(E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(piperidin-1-yl-2,3,4,5,6-d5)but-2-enamide
分子式	C24H20D5ClFN5O2
分子量	475.0
InChI
InChI Key
Canonical SMILES	ClC1=C(F)C=CC(NC2=NC=NC3=C2C=C(NC(/C=C/CN4C([2H])C([2H])C([2H])C([2H])C4[2H])=O)C(OC)=C3)=C1