D-Glucosamine-13C Hydrochloride is chemically (2R,3R,4S,5R)-2-amino-3,4,5,6-tetrahydroxyhexanal-1-13C hydrochloride. D-Glucosamine-13C Hydrochloride is supplied with detailed characterization data compliant with regulatory guideline. D-Glucosamine-13C Hydrochloride can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Glucosamine. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.
Glucosamine Hydrochloride is chemically (2R,3R,4S,5R)-2-amino-3,4,5,6-tetrahydroxyhexanal hydrochloride. Glucosamine Hydrochloride is supplied with detailed characterization data compliant with regulatory guideline. Glucosamine Hydrochloride can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Glucosamine. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.
Glucosamine Sulfate Potassium Chloride is chemically Bis(2-amino-2-deoxy-beta-D-glucopyranose) Sulfate Potassium Chloride Complex. Glucosamine Sulfate Potassium Chloride is supplied with detailed characterization data compliant with regulatory guideline. Glucosamine Sulfate Potassium Chloride can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Glucosamine. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.
N-N-Butyryl-D-Glucosamine is chemically N-((3R,4R,5S,6R)-2,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)butyramide. N-N-Butyryl-D-Glucosamine is supplied with detailed characterization data compliant with regulatory guideline. N-N-Butyryl-D-Glucosamine can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Glucosamine. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.
Route of Synthesis (ROS) of N-Acetyl-D-glucosamine CAS 7512-17-6
Conditions
Yield
With Biolacta N5 In N,N-dimethylhexanamide at 30℃; pH=5; aq. buffer; Enzymatic reaction; regioselective reaction;
Experimental Procedure 4.5. General procedure for transglycosylation reactions using glycoconjugates General procedure: A solution of 51.2 mg (0.17 M) p-nitrophenyl-β-d-galactopyranoside (donor) and 188 mg (0.85 M) of N-acetylglucosamine (acceptor) in 1 mL of green solvent (2 M)-buffer mixture was pre-equilibrated to 30 °C. Afterwards, 155 μmol/min (U) of β-galactosidase were added to the reaction mixture. Reaction was monitored by HPLC UV-vis and final products analysed by HPLC with an evaporative light scattering detector (ELSD). The reaction was stopped by heating the sample at 100 °C for 5 min.Isolation of disaccharides was done by carbon/Celite (50% m/m), chromatography, the column was eluted with milliQ water and ethanol gradient (from 5% to 15% v/v). [21] and [26] The structures of the disaccharides (Gal-β(1→4)GlcNAc and Gal-β(1→6)GlcNAc) were assigned by 1H and 13C NMR (D2O, 700 MHz), spectra were identical to previous references. [21], [26] and [27]In order to determine the effect of non-proteic substances present in Biolacta preparation in the reaction yield, transglycosylation reactions were carried out using semipurified (lyophilized) enzyme. The best performing solvents were chosen in view of the previous results, using crude extracts and setting the reactions with semipurified enzymes. The transglycosylation conditions were the same mentioned above and the reaction was monitored using HPLC-ELSD.For functionalized disaccharides the same protocol previously described was used, and different glycoconjugates as acceptors were added. A solution of 51.2 mg (0.17 M) pNP-β-Gal (donor) and the different monosaccharides functionalized 1 and 2 (0.51 M).
86%
With triethyl phosphate; sodium acetate; β-galactosidase In water at 30℃; galactosylation; Enzymatic reaction;
Safety and Hazards
GHS Hazard Statements
Not Classified
Source: European Chemicals Agency (ECHA) License Note: Use of the information, documents and data from the ECHA website is subject to the terms and conditions of this Legal Notice, and subject to other binding limitations provided for under applicable law, the information, documents and data made available on the ECHA website may be reproduced, distributed and/or used, totally or in part, for non-commercial purposes provided that ECHA is acknowledged as the source: “Source: European Chemicals Agency, http://echa.europa.eu/”. Such acknowledgement must be included in each copy of the material. ECHA permits and encourages organisations and individuals to create links to the ECHA website under the following cumulative conditions: Links can only be made to webpages that provide a link to the Legal Notice page. License URL: https://echa.europa.eu/web/guest/legal-notice Record Name: (1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino-carbenium hexafluorophosphate URL: https://echa.europa.eu/information-on-chemicals/cl-inventory-database/-/discli/details/213446 Description: The information provided here is aggregated from the “Notified classification and labelling” from ECHA’s C&L Inventory. Read more: https://echa.europa.eu/information-on-chemicals/cl-inventory-database
Other Data
Storage
Stored at room temperature for long time; Sealed and keep away from light.
Use Pattern
N-Acetylglucosamine is a versatile ingredient widely used in pharmaceuticals, cosmetics, health supplements, and biomedical materials. Its primary sources include animal extraction and microbial fermentation. In the pharmaceutical field, it helps improve joint health, promotes cartilage matrix synthesis by chondrocytes, enhances cartilage repair, and alleviates joint pain. As a derivative of glucosamine, it supports skin health and tissue repair. In cosmetics, it stimulates the synthesis of hyaluronic acid (HA), enhancing skin hydration. It also repairs the skin barrier, reducing redness and sensitivity, while accelerating epidermal cell renewal and promoting wound healing.
Glucosamine is chemically 2-Amino-2-deoxy-D-glucopyranose (as per EP). Glucosamine is supplied with detailed characterization data compliant with regulatory guideline. Glucosamine can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Glucosamine. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.
Glucosamine EP Impurity E is chemically 5-(Hydroxymethyl)furan-2-carbaldehyde (as per EP). It is also known as 5-Hydroxymethylfurfural (EP). Glucosamine EP Impurity E is supplied with detailed characterization data compliant with regulatory guideline. Glucosamine EP Impurity E can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Glucosamine. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.
2-(Acetylamino)-2-deoxy-D-glucopyranose (as per EP)
分子式
C8H15NO6
分子量
221.2
InChI
InChI Key
Canonical SMILES
OC1[C@H](NC(C)=O)[C@H]([C@@H]([C@@H](CO)O1)O)O
Physical Data
Appearance
No data available
Solubility
No data available
Flash Point
No data available
Refractive index
No data available
Sensitivity
No data available
Melting Point
No data available
Spectra
No data available
Route of Synthesis (ROS)
No data available
Safety and Hazards
No data available
Other Data
HS Code
382290
Storage
At room temperature and away from light
Related Chemicals
Use Pattern
Glucosamine EP Impurity A is chemically 2-(Acetylamino)-2-deoxy-D-glucopyranose (as per EP). It is also known as N-Acetylglucosamine (EP). Glucosamine EP Impurity A is supplied with detailed characterization data compliant with regulatory guideline. Glucosamine EP Impurity A can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Glucosamine. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.
Glucosamine Sulfate Sodium Salt is chemically ((2R,3R,4S,5R)-3,4,5,6-Tetrahydroxy-1-oxohexan-2-yl)sulfamic acid, sodium salt. Glucosamine Sulfate Sodium Salt is supplied with detailed characterization data compliant with regulatory guideline. Glucosamine Sulfate Sodium Salt can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Glucosamine. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.
Glucosamine EP Impurity B is chemically (1R,1′R,2S,2′S,3R,3′R)-1,1′-Pyrazine-2,5-diylbis(butane-1,2,3,4-tetrol) (as per EP). It is also known as Fructosazine (EP). Glucosamine EP Impurity B is supplied with detailed characterization data compliant with regulatory guideline. Glucosamine EP Impurity B can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Glucosamine. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.
