Larotrectinib Enantiomer Impurity CAS#: N/A

By great_watson-int,
Identification Physical Data Spectra
Route of Synthesis (ROS) Safety and Hazards Other Data

Identification

英文名 Larotrectinib Enantiomer Impurity
分子结构
CAS编号 N/A
EINECS Number
MDL Number
Beilstein Registry Number
别名 (R)-N-(5-((S)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide sulfate
分子式 C21H22F2N6O2 : H2SO4
分子量 428.4 : 98.1
InChI
InChI Key
Canonical SMILES O=S(O)(O)=O.O=C(N1C[C@H](O)CC1)NC2=C3N=C(N4[C@H](C5=CC(F)=CC=C5F)CCC4)C=CN3N=C2

Physical Data

Appearance No data available
Solubility No data available
Flash Point No data available
Refractive index No data available
Sensitivity No data available
Melting Point No data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

No data available

Other Data

HS Code 382290
Storage At room temperature and away from light
Related Chemicals 2409590-08-3 (free base)
Use Pattern
Larotrectinib Enantiomer Impurity is chemically (R)-N-(5-((S)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide sulfate. Larotrectinib Enantiomer Impurity is supplied with detailed characterization data compliant with regulatory guideline. Larotrectinib Enantiomer Impurity can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Larotrectinib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

Larotrectinib Nitroso Impurity 1 CAS#: N/A

By great_watson-int,
Identification Physical Data Spectra
Route of Synthesis (ROS) Safety and Hazards Other Data

Identification

英文名 Larotrectinib Nitroso Impurity 1
分子结构
CAS编号 N/A
EINECS Number
MDL Number
Beilstein Registry Number
别名 (R)-2-(2,5-Difluorophenyl)-1-nitrosopyrrolidine
分子式 C10H10F2N2O
分子量 212.2
InChI
InChI Key
Canonical SMILES O=NN1[C@@H](C2=CC(F)=CC=C2F)CCC1

Physical Data

Appearance No data available
Solubility No data available
Flash Point No data available
Refractive index No data available
Sensitivity No data available
Melting Point No data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

No data available

Other Data

HS Code 382290
Storage At room temperature and away from light
Related Chemicals
Use Pattern
Larotrectinib Nitroso Impurity 1 is chemically (R)-2-(2,5-Difluorophenyl)-1-nitrosopyrrolidine. Larotrectinib Nitroso Impurity 1 is supplied with detailed characterization data compliant with regulatory guideline. Larotrectinib Nitroso Impurity 1 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Larotrectinib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

Larotrectinib Impurity 13 CAS#: 1223404-68-9

By great_watson-int,
Identification Physical Data Spectra
Route of Synthesis (ROS) Safety and Hazards Other Data

Identification

英文名 Larotrectinib Impurity 13
分子结构
CAS编号 1223404-68-9
EINECS Number
MDL Number
Beilstein Registry Number
别名 (R)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
分子式 C21H22F2N6O2
分子量 428.4
InChI
InChI Key
Canonical SMILES FC(C=C1)=C(C=C1F)[C@@H]2N(C(C=CN3N=C4)=NC3=C4NC(N(C5)CC[C@H]5O)=O)CCC2

Physical Data

Appearance No data available
Solubility No data available
Flash Point No data available
Refractive index No data available
Sensitivity No data available
Melting Point No data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

No data available

Other Data

HS Code 382290
Storage At room temperature and away from light
Related Chemicals
Use Pattern
Larotrectinib Impurity 13 is chemically (R)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide. Larotrectinib Impurity 13 is supplied with detailed characterization data compliant with regulatory guideline. Larotrectinib Impurity 13 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Larotrectinib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

Larotrectinib Impurity 10 CAS#: 1218935-59-1

By great_watson-int,
Identification Physical Data Spectra
Route of Synthesis (ROS) Safety and Hazards Other Data

Identification

英文名 Larotrectinib Impurity 10
分子结构
CAS编号 1218935-59-1
EINECS Number
MDL Number
Beilstein Registry Number
别名 (R)-2-(2,5-difluorophenyl)pyrrolidine
分子式 C10H11F2N
分子量 183.2
InChI
InChI Key
Canonical SMILES FC(C=C1)=C([C@H]2CCCN2)C=C1F

Physical Data

Appearance No data available
Solubility No data available
Flash Point No data available
Refractive index No data available
Sensitivity No data available
Melting Point No data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

No data available

Other Data

HS Code 382290
Storage At room temperature and away from light
Related Chemicals 1218935-60-4 (HCl salt)
Use Pattern
Larotrectinib Impurity 10 is chemically (R)-2-(2,5-difluorophenyl)pyrrolidine. Larotrectinib Impurity 10 is supplied with detailed characterization data compliant with regulatory guideline. Larotrectinib Impurity 10 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Larotrectinib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

Larotrectinib Diastereomer Impurity CAS#: N/A

By great_watson-int,
Identification Physical Data Spectra
Route of Synthesis (ROS) Safety and Hazards Other Data

Identification

英文名 Larotrectinib Diastereomer Impurity
分子结构
CAS编号 N/A
EINECS Number
MDL Number
Beilstein Registry Number
别名 (S)-N-(5-((S)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide sulfate
分子式 C21H22F2N6O2 : H2SO4
分子量 428.4 : 98.1
InChI
InChI Key
Canonical SMILES O=S(O)(O)=O.O=C(N1C[C@@H](O)CC1)NC2=C3N=C(N4[C@H](C5=CC(F)=CC=C5F)CCC4)C=CN3N=C2

Physical Data

Appearance No data available
Solubility No data available
Flash Point No data available
Refractive index No data available
Sensitivity No data available
Melting Point No data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

No data available

Other Data

HS Code 382290
Storage At room temperature and away from light
Related Chemicals 2409589-59-7 (free base)
Use Pattern
Larotrectinib Diastereomer Impurity is chemically (S)-N-(5-((S)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide sulfate. Larotrectinib Diastereomer Impurity is supplied with detailed characterization data compliant with regulatory guideline. Larotrectinib Diastereomer Impurity can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Larotrectinib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

Larotrectinib Impurity 11 CAS#: 1223404-90-7

By great_watson-int,
Identification Physical Data Spectra
Route of Synthesis (ROS) Safety and Hazards Other Data

Identification

英文名 Larotrectinib Impurity 11
分子结构
CAS编号 1223404-90-7
EINECS Number
MDL Number
Beilstein Registry Number
别名 (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-nitropyrazolo[1,5-a]pyrimidine
分子式 C16H13F2N5O2
分子量 345.3
InChI
InChI Key
Canonical SMILES FC(C=C1)=C(C=C1F)[C@@H]2N(C(C=CN3N=C4)=NC3=C4[N](=O)=O)CCC2

Physical Data

Appearance No data available
Solubility No data available
Flash Point No data available
Refractive index No data available
Sensitivity No data available
Melting Point No data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

No data available

Other Data

HS Code 382290
Storage At room temperature and away from light
Related Chemicals
Use Pattern
Larotrectinib Impurity 11 is chemically (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-nitropyrazolo[1,5-a]pyrimidine. Larotrectinib Impurity 11 is supplied with detailed characterization data compliant with regulatory guideline. Larotrectinib Impurity 11 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Larotrectinib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

Larotrectinib Impurity 12 CAS#: 1223404-89-4

By great_watson-int,
Identification Physical Data Spectra
Route of Synthesis (ROS) Safety and Hazards Other Data

Identification

英文名 Larotrectinib Impurity 12
分子结构
CAS编号 1223404-89-4
EINECS Number
MDL Number
Beilstein Registry Number
别名 (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine
分子式 C16H14F2N4
分子量 300.3
InChI
InChI Key
Canonical SMILES FC(C=C1)=C(C=C1F)[C@@H]2N(C3=NC4=CC=NN4C=C3)CCC2

Physical Data

Appearance No data available
Solubility No data available
Flash Point No data available
Refractive index No data available
Sensitivity No data available
Melting Point No data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

No data available

Other Data

HS Code 382290
Storage At room temperature and away from light
Related Chemicals
Use Pattern
Larotrectinib Impurity 12 is chemically (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine. Larotrectinib Impurity 12 is supplied with detailed characterization data compliant with regulatory guideline. Larotrectinib Impurity 12 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Larotrectinib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

Larotrectinib Impurity 8 CAS#: 1223404-88-3

By great_watson-int,
Identification Physical Data Spectra
Route of Synthesis (ROS) Safety and Hazards Other Data

Identification

英文名 Larotrectinib Impurity 8
分子结构
CAS编号 1223404-88-3
EINECS Number
MDL Number
Beilstein Registry Number
别名 (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine
分子式 C16H15F2N5
分子量 315.3
InChI
InChI Key
Canonical SMILES FC(C=C1)=C(C=C1F)[C@@H]2N(C(C=CN3N=C4)=NC3=C4N)CCC2

Physical Data

Appearance No data available
Solubility No data available
Flash Point No data available
Refractive index No data available
Sensitivity No data available
Melting Point No data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

No data available

Other Data

HS Code 382290
Storage At room temperature and away from light
Related Chemicals
Use Pattern
Larotrectinib Impurity 8 is chemically (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine. Larotrectinib Impurity 8 is supplied with detailed characterization data compliant with regulatory guideline. Larotrectinib Impurity 8 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Larotrectinib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

Larotrectinib Impurity 7 CAS#: N/A

By great_watson-int,
Identification Physical Data Spectra
Route of Synthesis (ROS) Safety and Hazards Other Data

Identification

英文名 Larotrectinib Impurity 7
分子结构
CAS编号 N/A
EINECS Number
MDL Number
Beilstein Registry Number
别名 (S)-1-((5-((R)-2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)carbamoyl)pyrrolidin-3-yl hydrogen sulfate
分子式 C21H22F2N6O5S
分子量 508.5
InChI
InChI Key
Canonical SMILES O=S(O)(O[C@@H]1CN(C(NC2=C3N=C(N4[C@@H](C5=CC(F)=CC=C5F)CCC4)C=CN3N=C2)=O)CC1)=O

Physical Data

Appearance No data available
Solubility No data available
Flash Point No data available
Refractive index No data available
Sensitivity No data available
Melting Point No data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

No data available

Other Data

HS Code 382290
Storage At room temperature and away from light
Related Chemicals
Use Pattern
Larotrectinib Impurity 7 is chemically (S)-1-((5-((R)-2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)carbamoyl)pyrrolidin-3-yl hydrogen sulfate. Larotrectinib Impurity 7 is supplied with detailed characterization data compliant with regulatory guideline. Larotrectinib Impurity 7 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Larotrectinib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

Larotrectinib Impurity 9 CAS#: 1363380-51-1

By great_watson-int,
Identification Physical Data Spectra
Route of Synthesis (ROS) Safety and Hazards Other Data

Identification

英文名 Larotrectinib Impurity 9
分子结构
CAS编号 1363380-51-1
EINECS Number
MDL Number
Beilstein Registry Number
别名 5-Chloro-3-nitropyrazolo[1,5-a]pyrimidine
分子式 C6H3ClN4O2
分子量 198.6
InChI
InChI Key
Canonical SMILES O=[N](C1=C(N=C2Cl)N(C=C2)N=C1)=O

Physical Data

Appearance No data available
Solubility No data available
Flash Point No data available
Refractive index No data available
Sensitivity No data available
Melting Point No data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

No data available

Other Data

HS Code 382290
Storage At room temperature and away from light
Related Chemicals
Use Pattern
Larotrectinib Impurity 9 is chemically 5-Chloro-3-nitropyrazolo[1,5-a]pyrimidine. Larotrectinib Impurity 9 is supplied with detailed characterization data compliant with regulatory guideline. Larotrectinib Impurity 9 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Larotrectinib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.