Tezacaftor Metabolite CAS#: 1432656-97-7

By great_watson-int,
Identification Physical Data Spectra
Route of Synthesis (ROS) Safety and Hazards Other Data

Identification

英文名 Tezacaftor Metabolite
分子结构
CAS编号 1432656-97-7
EINECS Number
MDL Number
Beilstein Registry Number
别名 1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-N-((4R)-8-fluoro-2-hydroxy-4-(hydroxymethyl)-1,1-dimethyl-1,2,4,5-tetrahydro-[1,4]oxazepino[4,5-a]indol-9-yl)cyclopropane-1-carboxamide
分子式 C26H25F3N2O6
分子量 518.5
InChI
InChI Key
Canonical SMILES O=C(C1(C2=CC=C(O3)C(OC3(F)F)=C2)CC1)NC(C=C(C=C(C(C)(C4O)C)N5C[C@@H](O4)CO)C5=C6)=C6F

Physical Data

Appearance No data available
Solubility No data available
Flash Point No data available
Refractive index No data available
Sensitivity No data available
Melting Point No data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

No data available

Other Data

HS Code 382290
Storage At room temperature and away from light
Related Chemicals
Use Pattern
Tezacaftor Metabolite is chemically 1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-N-((4R)-8-fluoro-2-hydroxy-4-(hydroxymethyl)-1,1-dimethyl-1,2,4,5-tetrahydro-[1,4]oxazepino[4,5-a]indol-9-yl)cyclopropane-1-carboxamide. Tezacaftor Metabolite is supplied with detailed characterization data compliant with regulatory guideline. Tezacaftor Metabolite can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Tezacaftor. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

Tezacaftor Impurity 1 CAS#: 1294504-67-8

By great_watson-int,
Identification Physical Data Spectra
Route of Synthesis (ROS) Safety and Hazards Other Data

Identification

英文名 Tezacaftor Impurity 1
分子结构
CAS编号 1294504-67-8
EINECS Number
MDL Number
Beilstein Registry Number
别名 (R)-1-(5-amino-2-(1-(benzyloxy)-2-methylpropan-2-yl)-6-fluoro-1H-indol-1-yl)-3-(benzyloxy)propan-2-ol
分子式 C29H33FN2O3
分子量 476.6
InChI
InChI Key
Canonical SMILES O[C@@H](COCC1=CC=CC=C1)CN(C(C(C)(C)COCC2=CC=CC=C2)=C3)C(C3=C4)=CC(F)=C4N

Physical Data

Appearance No data available
Solubility No data available
Flash Point No data available
Refractive index No data available
Sensitivity No data available
Melting Point No data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

No data available

Other Data

HS Code 382290
Storage At room temperature and away from light
Related Chemicals
Use Pattern
Tezacaftor Impurity 1 is chemically (R)-1-(5-amino-2-(1-(benzyloxy)-2-methylpropan-2-yl)-6-fluoro-1H-indol-1-yl)-3-(benzyloxy)propan-2-ol. Tezacaftor Impurity 1 is supplied with detailed characterization data compliant with regulatory guideline. Tezacaftor Impurity 1 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Tezacaftor. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

Tezacaftor Enantiomer CAS#: 1152311-99-3

By great_watson-int,
Identification Physical Data Spectra
Route of Synthesis (ROS) Safety and Hazards Other Data

Identification

英文名 Tezacaftor Enantiomer
分子结构
CAS编号 1152311-99-3
EINECS Number
MDL Number
Beilstein Registry Number
别名 (S)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropane-1-carboxamide
分子式 C26H27F3N2O6
分子量 520.5
InChI
InChI Key
Canonical SMILES FC(O1)(F)OC2=C1C=CC(C3(CC3)C(NC4=C(F)C=C(N(C[C@H](O)CO)C(C(C)(C)CO)=C5)C5=C4)=O)=C2

Physical Data

Appearance No data available
Solubility No data available
Flash Point No data available
Refractive index No data available
Sensitivity No data available
Melting Point No data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

No data available

Other Data

HS Code 382290
Storage At room temperature and away from light
Related Chemicals
Use Pattern
Tezacaftor Enantiomer is chemically (S)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropane-1-carboxamide. Tezacaftor Enantiomer is supplied with detailed characterization data compliant with regulatory guideline. Tezacaftor Enantiomer can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Tezacaftor. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

Acetonide O-Benzyl Tezacaftor CAS#: N/A

By great_watson-int,
Identification Physical Data Spectra
Route of Synthesis (ROS) Safety and Hazards Other Data

Identification

英文名 Acetonide O-Benzyl Tezacaftor
分子结构
CAS编号 N/A
EINECS Number
MDL Number
Beilstein Registry Number
别名 (R)-N-(2-(1-(benzyloxy)-2-methylpropan-2-yl)-1-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-6-fluoro-1H-indol-5-yl)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane-1-carboxamide
分子式 C36H37F3N2O6
分子量 650.7
InChI
InChI Key
Canonical SMILES FC(O1)(F)OC2=C1C=CC(C3(CC3)C(NC4=C(F)C=C(N(C[C@@H]5COC(C)(C)O5)C(C(C)(C)COCC6=CC=CC=C6)=C7)C7=C4)=O)=C2

Physical Data

Appearance No data available
Solubility No data available
Flash Point No data available
Refractive index No data available
Sensitivity No data available
Melting Point No data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

No data available

Other Data

HS Code 382290
Storage At room temperature and away from light
Related Chemicals
Use Pattern
Acetonide O-Benzyl Tezacaftor is chemically (R)-N-(2-(1-(benzyloxy)-2-methylpropan-2-yl)-1-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-6-fluoro-1H-indol-5-yl)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane-1-carboxamide. Acetonide O-Benzyl Tezacaftor is supplied with detailed characterization data compliant with regulatory guideline. Acetonide O-Benzyl Tezacaftor can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Tezacaftor. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

Tezacaftor D6 CAS#: N/A

By great_watson-int,
Identification Physical Data Spectra
Route of Synthesis (ROS) Safety and Hazards Other Data

Identification

英文名 Tezacaftor D6
分子结构
CAS编号 N/A
EINECS Number
MDL Number
Beilstein Registry Number
别名 (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(2-(hydroxymethyl)propan-2-yl-1,1,1,3,3,3-d6)-1H-indol-5-yl)cyclopropane-1-carboxamide
分子式 C26H21D6F3N2O6
分子量 526.5
InChI
InChI Key
Canonical SMILES O=C(C1(C2=CC=C(OC(F)(F)O3)C3=C2)CC1)NC4=CC5=C(N(C[C@@H](O)CO)C(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])CO)=C5)C=C4F

Physical Data

Appearance No data available
Solubility No data available
Flash Point No data available
Refractive index No data available
Sensitivity No data available
Melting Point No data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

No data available

Other Data

HS Code 382290
Storage At room temperature and away from light
Related Chemicals
Use Pattern
Tezacaftor D6 is chemically (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(2-(hydroxymethyl)propan-2-yl-1,1,1,3,3,3-d6)-1H-indol-5-yl)cyclopropane-1-carboxamide. Tezacaftor D6 is supplied with detailed characterization data compliant with regulatory guideline. Tezacaftor D6 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Tezacaftor. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

O-Benzyl Tezacaftor CAS#: N/A

By great_watson-int,
Identification Physical Data Spectra
Route of Synthesis (ROS) Safety and Hazards Other Data

Identification

英文名 O-Benzyl Tezacaftor
分子结构
CAS编号 N/A
EINECS Number
MDL Number
Beilstein Registry Number
别名 (S)-N-(2-(1-(benzyloxy)-2-methylpropan-2-yl)-6-fluoro-1-(2-hydroxybutyl)-1H-indol-5-yl)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane-1-carboxamide
分子式 C34H35F3N2O5
分子量 608.7
InChI
InChI Key
Canonical SMILES FC(O1)(F)OC2=C1C=CC(C3(CC3)C(NC4=C(F)C=C(N(C[C@@H](O)CC)C(C(C)(C)COCC5=CC=CC=C5)=C6)C6=C4)=O)=C2

Physical Data

Appearance No data available
Solubility No data available
Flash Point No data available
Refractive index No data available
Sensitivity No data available
Melting Point No data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

No data available

Other Data

HS Code 382290
Storage At room temperature and away from light
Related Chemicals
Use Pattern
O-Benzyl Tezacaftor is chemically (S)-N-(2-(1-(benzyloxy)-2-methylpropan-2-yl)-6-fluoro-1-(2-hydroxybutyl)-1H-indol-5-yl)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane-1-carboxamide. O-Benzyl Tezacaftor is supplied with detailed characterization data compliant with regulatory guideline. O-Benzyl Tezacaftor can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Tezacaftor. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

Tezacaftor CAS#: 1152311-62-0

By great_watson-int,
Identification Physical Data Spectra
Route of Synthesis (ROS) Safety and Hazards Other Data

Identification

英文名 Tezacaftor
分子结构
CAS编号 1152311-62-0
EINECS Number
MDL Number
Beilstein Registry Number
别名 1-(2,2-Difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]cyclopropanecarboxamide
分子式 C26H27F3N2O6
分子量 520.5
InChI
InChI Key
Canonical SMILES O=C(C1(C2=CC=C(OC(F)(F)O3)C3=C2)CC1)NC4=CC5=C(N(C[C@@H](O)CO)C(C(C)(C)CO)=C5)C=C4F

Physical Data

Appearance No data available
Solubility No data available
Flash Point No data available
Refractive index No data available
Sensitivity No data available
Melting Point No data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

No data available

Other Data

HS Code 382290
Storage At room temperature and away from light
Related Chemicals
Use Pattern
Tezacaftor is chemically 1-(2,2-Difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]cyclopropanecarboxamide. Tezacaftor is supplied with detailed characterization data compliant with regulatory guideline. Tezacaftor can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Tezacaftor. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

Tezacaftor Acetone Adduct CAS#: 2687976-22-1

By great_watson-int,
Identification Physical Data Spectra
Route of Synthesis (ROS) Safety and Hazards Other Data

Identification

英文名 Tezacaftor Acetone Adduct
分子结构
CAS编号 2687976-22-1
EINECS Number
MDL Number
Beilstein Registry Number
别名 (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(5-(2,3-dihydroxypropyl)-7-fluoro-1,1,4,4-tetramethyl-1,3,4,5-tetrahydropyrano[4,3-b]indol-8-yl)cyclopropane-1-carboxamide
分子式 C29H31F3N2O6
分子量 560.6
InChI
InChI Key
Canonical SMILES FC(O1)(F)OC2=C1C=CC(C3(CC3)C(NC4=C(F)C=C(N(C[C@@H](O)CO)C5=C6C(C)(C)OCC5(C)C)C6=C4)=O)=C2

Physical Data

Appearance No data available
Solubility No data available
Flash Point No data available
Refractive index No data available
Sensitivity No data available
Melting Point No data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

No data available

Other Data

HS Code 382290
Storage At room temperature and away from light
Related Chemicals
Use Pattern
Tezacaftor Acetone Adduct is chemically (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(5-(2,3-dihydroxypropyl)-7-fluoro-1,1,4,4-tetramethyl-1,3,4,5-tetrahydropyrano[4,3-b]indol-8-yl)cyclopropane-1-carboxamide. Tezacaftor Acetone Adduct is supplied with detailed characterization data compliant with regulatory guideline. Tezacaftor Acetone Adduct can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Tezacaftor. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

Tezacaftor D4 CAS#: 1961280-24-9

By great_watson-int,
Identification Physical Data Spectra
Route of Synthesis (ROS) Safety and Hazards Other Data

Identification

英文名 Tezacaftor D4
分子结构
CAS编号 1961280-24-9
EINECS Number
MDL Number
Beilstein Registry Number
别名 (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropane-2,2,3,3-d4-1-carboxamide
分子式 C26H23D4F3N2O6
分子量 524.5
InChI
InChI Key
Canonical SMILES O=C(C1(C2=CC=C(OC(F)(F)O3)C3=C2)C([2H])([2H])C1([2H])[2H])NC4=CC5=C(N(C[C@@H](O)CO)C(C(C)(C)CO)=C5)C=C4F

Physical Data

Appearance No data available
Solubility No data available
Flash Point No data available
Refractive index No data available
Sensitivity No data available
Melting Point No data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

No data available

Other Data

HS Code 382290
Storage At room temperature and away from light
Related Chemicals
Use Pattern
Tezacaftor D4 is chemically (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropane-2,2,3,3-d4-1-carboxamide. Tezacaftor D4 is supplied with detailed characterization data compliant with regulatory guideline. Tezacaftor D4 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Tezacaftor. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

Acetonide Tezacaftor CAS#: 1152311-90-4

By great_watson-int,
Identification Physical Data Spectra
Route of Synthesis (ROS) Safety and Hazards Other Data

Identification

英文名 Acetonide Tezacaftor
分子结构
CAS编号 1152311-90-4
EINECS Number
MDL Number
Beilstein Registry Number
别名 (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropane-1-carboxamide
分子式 C29H31F3N2O6
分子量 560.6
InChI
InChI Key
Canonical SMILES FC(O1)(F)OC2=C1C=CC(C3(CC3)C(NC4=C(F)C=C(N(C[C@@H]5COC(C)(C)O5)C(C(C)(C)CO)=C6)C6=C4)=O)=C2

Physical Data

Appearance No data available
Solubility No data available
Flash Point No data available
Refractive index No data available
Sensitivity No data available
Melting Point No data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

No data available

Other Data

HS Code 382290
Storage At room temperature and away from light
Related Chemicals
Use Pattern
Acetonide Tezacaftor is chemically (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropane-1-carboxamide. Acetonide Tezacaftor is supplied with detailed characterization data compliant with regulatory guideline. Acetonide Tezacaftor can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Tezacaftor. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.