1-(2-NAPHTHYL)METHANAMINE CAS#: 2018-90-8; 凯望编码 (ChemWhat Code): 201624

IdentificationPhysical DataSpectra
Route of Synthesis (ROS)Safety and HazardsOther Data

Identification

英文名1-(2-NAPHTHYL)METHANAMINE
IUPAC Namenaphthalen-2-ylmethanamine
分子结构1-2-NAPHTHYLMETHANAMINE-CAS-2018-90-8
CAS编号 2018-90-8
MDL NumberMFCD01529867
别名1-(2-NAPHTHYL)METHANAMINE
899-666-0
2018-90-8
2-Naphthalenemethanamine
naphthalen-2-ylmethanamine
2-(Aminomethyl)naphthalene
2-naphthylmethanamine
MFCD01529867
2-Aminomethylnaphthalene
(naphthalen-2-yl)methanamine
(naphthalene-2-yl)methylamine
Naphthalen-2-methylamine
C-Naphthalen-2-yl-methylamine
2-naphthylmethylamine
2-Aminomethylnapthalene
2-naphthalenemethylamine
SCHEMBL42223
SCHEMBL131652
SCHEMBL2003901
SCHEMBL6643495
SCHEMBL6897074
C-naphethalene-2-yl-methylamine
SCHEMBL27678365
(C-naphthalene-2-yl)methylamine
DTXSID40174012
XBCAHQUVHHVHHL-UHFFFAOYSA-N
AKOS000133202
CS-W002778
FN15510
SB76533
BS-13623
SY023509
EN300-33147
AB01018358-01
1-(2-Naphthyl) methanamine;Naphthalen-2-methylamine
分子式C11H11N 
分子量157.21
InChIInChI=1S/C11H11N/c12-8-9-5-6-10-3-1-2-4-11(10)7-9/h1-7H,8,12H2
InChI KeyXBCAHQUVHHVHHL-UHFFFAOYSA-N
SMILESC1=CC=C2C=C(C=CC2=C1)CN
Patent Information
Patent IDTitlePublication Date
CN114805106Preparation method of amide compound2022
CN114773252Chiral amino indoline derivative as well as preparation method and application thereof2022
CN106928037Preparation method of carvone2017
CN107417623One-step synthesis method of 5-diarylamino benzimidazole derivatives2017
EP2810944HETEROCYCLIC COMPOUND HAVING ANTI-HIV ACTIVITY2014
US2007/179115Purinenucleoside derivative modified in 8-position and medical use thereof2007
US6337398Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors2002

Physical Data

AppearanceWhite powder
Melting Point, °C
55 – 57
55 – 56
55 – 56
269
58
59 – 60
60
Boiling Point, °CPressure (Boiling Point), Torr
143 – 1478
18024
148 – 14912

Spectra

Description (NMR Spectroscopy)Nucleus (NMR Spectroscopy)Solvents (NMR Spectroscopy)Frequency (NMR Spectroscopy), MHz
Chemical shifts, Spectrum1H
dimethylsulfoxide-d6
Chemical shifts, Spectrum13Cdimethylsulfoxide-d6
Chemical shifts, Spectrum1Hchloroform-d1
Chemical shifts1Hchloroform-d1
Chemical shifts, Spectrum1Hchloroform-d1400.1
Chemical shifts, Spectrum13Cchloroform-d1100.6
Chemical shifts, Spectrum1Hchloroform-d1
Description (IR Spectroscopy)Solvent (IR Spectroscopy)
Bandspotassium bromide
ATR (attenuated total reflectance), Bandsneat (no solvent, solid phase)
ATR (attenuated total reflectance), Bands
FT-IR, in KBr
BandsKBr
BandsKBr

Route of Synthesis (ROS)

Route of Synthesis (ROS) of 1-(2-NAPHTHYL)METHANAMINE CAS 2018-90-8
Route of Synthesis (ROS) of 1-(2-NAPHTHYL)METHANAMINE CAS 2018-90-8
ConditionsYield
With piperidin-2-one; sodium tetrahydroborate; N,N-diisopropyl-4H-benzo[d][1,3,2]dioxaborinin-2-amine; ammonia In 1,2-dichloro-ethane at 20℃;99%
With ammonia; hydrogen In methanol at 120℃; under 15001.5 Torr; for 4h; Autoclave;

Experimental Procedure
A method to catalyze the reductive amination of aldehydes and ketones to prepare primary amines, except that “benzaldehyde” in step 2) of Example 1 is replaced with “2-naphthaldehyde” and “reaction at 90°C for 4h” is replaced with “120°C” Except for the reaction for 4h”, everything else was exactly the same as in Example 1. The yield of 2-naphthylmethylamine was 99%.		99%
With ammonium hydroxide; hydrogen In ethanol at 130℃; under 7500.75 Torr; for 12h; Autoclave;

Experimental Procedure
2.4. General procedure of the reductive amination
General procedure: The reductive amination of carbonyl compounds was performed in a 50 mL stainless steel autoclave reactor. In a typical run, benzaldehyde (1 mmol), Co(at)NC-800 (20 mg), ethanol (8 mL) and NH3.H2O (26.5 wt%, 2 mL) were charged into the reactor, and then the autoclave reactor was closed. The reactor was flushed with H2 for several times to remove air, and then charged with 1 MPa H2 at room temperature. The reaction was then carriedout at 130 °C for 12 h with a stirring rate of 1000 RPM. After reaction,the reaction mixture was cooled down to room temperature and then depressurized. Then, the products in the reaction mixture were detected by gas chromatography by the use of ethylbenzene as the internal standard. The products were also identified by GC/MS (Shimadzu GCMS-QP2010) equipped with Agilent capillary column DB-5MS.		93.6%

Safety and Hazards

Pictogram(s)exclamation-markenvironment
SignalWarning
GHS Hazard StatementsH302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
H411 (50%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]
Precautionary Statement CodesP261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501
(The corresponding statement to each P-code can be found at the GHS Classification page.)

Other Data

TransportationStore at around 0 ℃
HS Code
StorageStore at around 0 ℃
Shelf Life1 year
Market Price
Druglikeness
Lipinski rules component
分子量157.215
logP2.41
HBA1
HBD1
Matching Lipinski Rules4
Veber rules component
Polar Surface Area (PSA)26.02
Rotatable Bond (RotB)1
Matching Veber Rules2
Use Pattern
2-(Aminomethyl)naphthalene CAS 2018-90-8 is mainly used as an intermediate in pharmaceutical synthesis and organic chemistry for producing functional compounds.

试剂采购

没有试剂厂商? 向凯望发送快速询价
想要被列为试剂厂商? (付费服务) 点击这里联系凯望

认证生产商

Caming Pharmaceutical Limitedhttp://www.caming.com/
想要被列为认证生产商 (需要通过认证)? 请下载并填写 这份表格并发邮件到approved-manufacturers@chemwhat.com

其他供应商

Watson International Limited 访问Watson官网

如需其他帮助，请联系我们

联系我们获取其它信息或服务 点击这里联系凯望