| 英文名 |
1,5-anhydro-D-fructose dehydratase |
| Example Structure |
 |
| 别名 |
1,5-anhydro-D-arabino-hex-2-ulose dehydratase, 1,5-anhydro-D-fructose 4-dehydratase, 1,5-anhydro-D-fructose hydro-lyase, 1,5-anhydro-D-fructose hydrolyase, AF dehydratase, AFDH |
| EC Number |
4.2.1.111 |
| CAS编号 |
|
| Comments |
This enzyme catalyses one of the steps in the anhydrofructose pathway, which leads to the degradation of glycogen and starch via 1,5-anhydro-D-fructose [1,2]. The other enzymes involved in this pathway are EC?4.2.1.110?(aldos-2-ulose dehydratase), EC?4.2.2.13?[exo-(1¡ú4)-¦Á-D-glucan lyase] and EC?5.3.2.7?(ascopyrone tautomerase). Requires divalent (Ca2+?or Mg2+) or monovalent cations (Na+) for optimal activity. Unlike EC?4.2.1.110, aldos-2-ulose dehydratase, the enzyme is specific for 1,5-anhydro-D-fructose as substrate and shows no activity towards aldose-2-uloses such as 2-dehydroglucose [1,2,3]. In addition, it is inhibited by its end-product ascopyrone M [2] and it cannot convert the end-product ascopyrone M into microthecin, as can EC?4.2.1.110. |
| Cofactor |
Ca2+?or?Na+?or?Mg2+ |
| History |
|
| Reactions |
1,5-anhydro-D-fructose = 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H(2)O. |
