| 英文名 |
1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) |
| Example Structure |
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| 别名 |
1,5-anhydro-D-fructose reductase, 1,5-anhydro-D-fructose reductase (ambiguous), AF reductase, AFR, AKR1E1, More, NADPH dependent 1,5-anhydro-D-fructose reductase |
| EC Number |
1.1.1.292 |
| CAS编号 |
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| Comments |
This enzyme is present in some but not all Rhizobium species and belongs in the GFO/IDH/MocA protein family [2]. This enzyme differs from hepatic 1,5-anhydro-D-fructose reductase, which yields 1,5-anhydro-D-glucitol as the product (see EC 1.1.1.263). In Sinorhizobium morelense, the product of the reaction, 1,5-anhydro-D-mannitol, can be further metabolized to D-mannose [1]. The enzyme also reduces 1,5-anhydro-D-erythro-hexo-2,3-diulose and 2-ketoaldoses (called osones), such as D-glucosone (D-arabino-hexos-2-ulose) and 6-deoxy-D-glucosone. It does not reduce common aldoses and ketoses, or non-sugar aldehydes and ketones [1]. |
| Cofactor |
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| History |
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| Reactions |
1,5-anhydro-D-mannitol + NADP(+) = 1,5-anhydro-D-fructose + Nadph. |
