| 英文名 |
(1R,4R,5S)-(-)-guaia-6,10(14)-diene synthase |
| Example Structure |
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| 别名 |
STC5 |
| EC Number |
4.2.3.165 |
| CAS编号 |
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| Comments |
The original enzyme (STC5) from the fungus?Fusarium fujikuroi?is inactive because of a critically naturally occuring mutation that leads to an asparagine to lysine exchange in the NSE (Asn-Ser-Glu) triad, a highly conserved motif of type I terpene cyclases. Sequence correction by site-directed mutagenesis (K288N) restores activity. |
| Cofactor |
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| History |
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| Reactions |
(2E,6E)-farnesyl diphosphate = (1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate. |
