| 英文名 |
2-(3-amino-3-carboxypropyl)histidine synthase |
| Example Structure |
 |
| 别名 |
diphthine synthase, Dph2, DPH4, PhDph2, S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase |
| EC Number |
2.5.1.108 |
| CAS编号 |
|
| Comments |
A [4Fe-4S] enzyme that modifies a histidine residue of the translation elongation factor 2 (EF2) via a 3-amino-3-carboxypropyl radical. The enzyme is present in archae and eukaryotes but not in eubacteria. The relevant histidine of EF2 is His715 in mammals, His699 in yeast and His600 in Pyrococcus horikoshii. Part of diphthamide biosynthesis. |
| Cofactor |
iron-sulfur |
| History |
|
| Reactions |
L-histidine-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-((3S)-3-amino-3-carboxypropyl)-L-histidine-[translation elongation factor 2] + S-methyl-5′-thioadenosine. |
