| 英文名 |
2-amino-4-deoxychorismate synthase |
| Example Structure |
 |
| 别名 |
2-amino-2-deoxyisochorismate (ADIC) synthase, 2-amino-2-deoxyisochorismate synthase, 2-amino-2desoxyisochorismate synthase, ADCS, ADIC synthase, aminodeoxyisochorismate synthase, PabA, PhzE, SgcD |
| EC Number |
2.6.1.86 |
| CAS编号 |
|
| Comments |
Requires Mg2+. The reaction occurs in the reverse direction to that shown above. In contrast to most anthranilate-synthase I (ASI) homologues, this enzyme is not inhibited by tryptophan. In?Streptomyces globisporus, the sequential action of this enzyme and EC?1.3.99.24, 2-amino-4-deoxychorismate dehydrogenase, leads to the formation of the benzoxazolinate moiety of the enediyne antitumour antibiotic C-1027 [1,2]. In certain Pseudomonads the enzyme participates in the biosynthesis of phenazine, a precursor for several compounds with antibiotic activity [3,4]. |
| Cofactor |
Mg2+ |
| History |
|
| Reactions |
(2S)-2-amino-4-deoxychorismate + L-glutamate = chorismate + L-glutamine. |
