| 英文名 |
2-epi-5-epi-valiolone synthase |
| Example Structure |
 |
| 别名 |
AbcC, AcbC, C7-cyclitol synthase, CetA, EVS, SalQ, sedoheptulose 7-phosphate cyclase, SH7PC, ValA |
| EC Number |
4.2.3.152 |
| CAS编号 |
|
| Comments |
The enzyme is highly specific for ¦Á-D-sedoheptulopyranose 7-phosphate. It requires a divalent metal ion (Zn2+?or Co2+) and an NAD+?cofactor, which is transiently reduced during the reaction. The enzyme is involved in the biosynthesis of C7N-aminocyclitol natural products, such as the valienamine moiety of the antidiabetic drug acarbose and the crop protectant validamycin A.?cf. EC?4.2.3.155, 2-epi-valiolone synthase and EC?4.2.3.154, desmethyl-4-deoxygadusol synthase. |
| Cofactor |
|
| History |
|
| Reactions |
D-sedoheptulose 7-phosphate = 2-epi-5-epi-valiolone + phosphate. |
