| 英文名 |
2-heptyl-4(1H)-quinolone synthase |
| Example Structure |
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| 别名 |
2,4-dihydroxyquinoline synthase, PqsD, PsqD |
| EC Number |
2.3.1.230 |
| CAS编号 |
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| Comments |
The enzyme, characterized from the bacterium Pseudomonas aeruginosa, is a heterodimeric complex. The PqsC subunit acquires an octanoyl group from octanoyl-CoA and attaches it to an internal cysteine residue. Together with the PqsB subunit, the proteins catalyse the coupling of the octanoyl group with (2-aminobenzoyl)acetate, leading to decarboxylation and dehydration events that result in closure of the quinoline ring. |
| Cofactor |
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| History |
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| Reactions |
Octanoyl-CoA + 2-aminobenzoylacetate = 2-heptyl-4(1H)-quinolone + CoA + CO(2) + H(2)O. |
