| 英文名 |
2-methylbutanoate polyketide synthase |
| Example Structure |
 |
| 别名 |
LDKS, LocF, lovastatin diketide synthase, LovF |
| EC Number |
2.3.1.244 |
| CAS编号 |
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| Comments |
This polyketide synthase enzyme forms the (S)-2-methylbutanoate side chain during lovastatin biosynthesis by the filamentous fungus Aspergillus terreus. The overall reaction comprises a single condensation reaction followed by ¦Á-methylation, ¦Â-ketoreduction, dehydration, and ¦Á,¦Â enoyl reduction. |
| Cofactor |
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| History |
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| Reactions |
2 malonyl-CoA + [2-methylbutanoate polyketide synthase] + 2 Nadph + S-adenosyl-L-methionine = (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CoA + 2 CO(2) + 2 NADP(+) + S-adenosyl-L- homocysteine + H(2)O. |
