| 英文名 |
2′-phospho-ADP-ribosyl cyclase/2′-phospho-cyclic-ADP-ribose transferase |
| Example Structure |
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| 别名 |
2′-phospho-cyclic-ADP-ribose transferase, ADP-ribosyl cyclase 1, ADPRC 1, BST1, CD38, diphosphopyridine nucleosidase |
| EC Number |
2.4.99.20 |
| CAS编号 |
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| Comments |
This multiunctional enzyme catalyses both the removal of nicotinamide from NADP+, forming 2′-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming NAADP+, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes. In addition, the enzyme also catalyses EC 3.2.2.6, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase. |
| Cofactor |
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| History |
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| Reactions |
NADP(+) + nicotinate = nicotinate-adenine dinucleotide phosphate + nicotinamide. |
