| 英文名 |
2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase |
| Example Structure |
 |
| 别名 |
AF0464, CrtI homologue, digeranylgeranylglycerophospholipid reductase, geranylgeranyl reductase, GGR, MA1484, MA1492, MA_1484, MA_1492, phytoene dehydrogenase family protein, Sa-GGR, SaGGR, Ta0516 |
| EC Number |
1.3.7.11 |
| CAS编号 |
|
| Comments |
A flavoprotein (FAD). The enzyme is involved in the biosynthesis of archaeal membrane lipids. It catalyses the reduction of all 8 double bonds in 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipids and all 4 double bonds in 3-O-geranylgeranyl-sn-glycerol phospholipids with comparable activity. Unlike EC 1.3.1.101, 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase [NAD(P)H], this enzyme shows no activity with NADPH, and requires a dedicated ferredoxin [4]. |
| Cofactor |
FAD |
| History |
|
| Reactions |
A 2,3-bis-(O-phytanyl)-sn-glycero-phospholipid + 16 oxidized ferredoxin [iron-sulfur] cluster = a 2,3-bis-(O-geranylgeranyl)-sn-glycero- phospholipid + 16 reduced ferredoxin [iron-sulfur] cluster + 16 H(+). |
