| 英文名 |
23S rRNA (cytidine1920-2′-O)-methyltransferase |
| Example Structure |
 |
| 别名 |
2′-O-methyltransferase, TlyA, TlyAI, TlyAII |
| EC Number |
2.1.1.226 |
| CAS编号 |
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| Comments |
The bifunctional enzyme from Mycobacterium tuberculosis 2′-O-methylates cytidine1920 in helix 69 of 23S rRNA and cytidine1409 in helix 44 of 16S rRNA (cf. EC 2.1.1.227, 16S rRNA (cytidine1409-2′-O)-methyltransferase). These methylations result in increased susceptibility to the antibiotics capreomycin and viomycin. |
| Cofactor |
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| History |
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| Reactions |
S-adenosyl-L-methionine + cytidine(1920) in 23S rRNA = S-adenosyl-L- homocysteine + 2′-O-methylcytidine(1920) in 23S rRNA. |
