23S rRNA (uridine2479-2′-O)-methyltransferase EC#: 2.1.1.208; 凯望编码 (ChemWhat Code): 1376442

英文名 23S rRNA (uridine2479-2′-O)-methyltransferase
Example Structure Example Structure of 23S rRNA (uridine2479-2'-O)-methyltransferase EC#: 2.1.1.208
别名 AviRb
EC Number 2.1.1.208
CAS编号
Comments Streptomyces viridochromogenes produces the antibiotic avilamycin A which binds to the 50S ribosomal subunit to inhibit protein synthesis. To protect itself from the antibiotic, Streptomyces viridochromogenes utilizes two methyltransferases, 23S rRNA (uridine2479-2′-O)-methyltransferase and EC 2.1.1.209 [23S rRNA (guanine2535-N1)-methyltransferase], whose actions confer avilamycin resistance to the RNA.
Cofactor
History
Reactions S-adenosyl-L-methionine + uridine(2479) in 23S rRNA = S-adenosyl-L- homocysteine + 2′-O-methyluridine(2479) in 23S rRNA.

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