| 英文名 |
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase |
| Example Structure |
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| 别名 |
NcsB1 |
| EC Number |
2.1.1.303 |
| CAS编号 |
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| Comments |
The enzyme from the bacterium Streptomyces carzinostaticus is involved in the biosynthesis of 2-hydroxy-7-methoxy-5-methyl-1-naphthoate. This compound is part of the enediyne chromophore of the antitumor antibiotic neocarzinostatin. In vivo the enzyme catalyses the regiospecific methylation at the 7-hydroxy group of its native substrate 2,7-dihydroxy-5-methyl-1-naphthoate. In vitro it also recognizes other dihydroxynaphthoic acids and catalyses their regiospecific O-methylation. |
| Cofactor |
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| History |
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| Reactions |
S-adenosyl-L-methionine + 2,7-dihydroxy-5-methyl-1-naphthoate = S-adenosyl-L-homocysteine + 2-hydroxy-7-methoxy-5-methyl-1-naphthoate. |
