27S pre-rRNA (guanosine2922-2′-O)-methyltransferase EC#: 2.1.1.167; 凯望编码 (ChemWhat Code): 1376372

英文名 27S pre-rRNA (guanosine2922-2′-O)-methyltransferase
Example Structure Example Structure of 27S pre-rRNA (guanosine2922-2'-O)-methyltransferase EC#: 2.1.1.167
别名 Spb1p
EC Number 2.1.1.167
CAS编号
Comments Spb1p is a site-specific 2′-O-ribose RNA methyltransferase that catalyses the formation of 2′-O-methylguanosine2922, a universally conserved position of the catalytic center of the ribosome that is essential for translation. 2′-O-Methylguanosine2922 is formed at a later stage of the processing, during the maturation of of the 27S pre-rRNA. In absence of snR52, Spb1p can also catalyse the formation of uridine2921 [1].
Cofactor
History
Reactions S-adenosyl-L-methionine + guanosine(2922) in 27S pre-rRNA = S-adenosyl-L- homocysteine + 2′-O-methylguanosine(2922) in 27S pre-rRNA.

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