| 英文名 |
3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase |
| Example Structure |
 |
| 别名 |
3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione 4-hydroxylase, HsaAB |
| EC Number |
1.14.14.12 |
| CAS编号 |
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| Comments |
This bacterial enzyme participates in the degradation of several steroids, including cholesterol and testosterone. It can use either FADH or FMNH2 as flavin cofactor. The enzyme forms a two-component system with a reductase (HsaB) that utilizes NADH to reduce the flavin, which is then transferred to the oxygenase subunit. |
| Cofactor |
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| History |
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| Reactions |
3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH(2) + O(2) = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + Fmn + H(2)O. |
