| 英文名 |
3-O-phospho-polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol 3-phospho-methyltransferase |
| Example Structure |
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| 别名 |
chain-terminating dual kinase/methyltransferase, WbdD, WbdDO9a |
| EC Number |
2.1.1.294 |
| CAS编号 |
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| Comments |
The enzyme is involved in the biosynthesis of the polymannose O-polysaccharide in the outer leaflet of the membrane of Escherichia coli serotype O9a. O-Polysaccharide structures vary extensively because of differences in the number and type of sugars in the repeat unit. The dual kinase/methylase WbdD also catalyses the preceding phosphorylation of ¦Á-D-Man-(1¡ú2)-¦Á-D-Man-(1¡ú2)-[¦Á-D-Man-(1¡ú3)-¦Á-D-Man-(1¡ú3)-¦Á-D-Man-(1¡ú2)-¦Á-D-Man-(1¡ú2)]N-¦Á-D-Man-(1¡ú3)-¦Á-D-Man-(1¡ú3)-¦Á-D-Man-(1¡ú3)-¦Á-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol (cf. EC 2.7.1.181, polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol kinase). |
| Cofactor |
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| History |
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| Reactions |
S-adenosyl-L-methionine + 3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man- (1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D- Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3))(n)-alpha-D-Man-(1->3)- alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol = S-adenosyl-L-homocysteine + 3-O-methylphospho-alpha-D-Man-(1->2)-alpha- D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)- alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3))(n)-alpha-D-Man- (1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-ditrans,octacis- undecaprenol. |
