| 英文名 |
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase |
| Example Structure |
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| 别名 |
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate 24-hydroxylase, 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA oxidase, alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA oxidase, THC-CoA oxidase, THCA-CoA oxidase, THCCox, Trihydroxycoprostanoyl-CoA oxidase |
| EC Number |
1.17.99.3 |
| CAS编号 |
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| Comments |
Requires ATP. The reaction in mammals possibly involves dehydrogenation to give a 24(25)-double bond followed by hydration [1]. However, in amphibians such as the Oriental fire-bellied toad (Bombina orientalis), it is probable that the product is formed via direct hydroxylation of the saturated side chain of (25R)-3¦Á,7¦Á,12¦Á-trihydroxy-5¦Â-cholestan-26-oate and not via hydration of a 24(25) double bond [5]. In microsomes, the free acid is preferred to the coenzyme A ester, whereas in mitochondria, the coenzyme A ester is preferred to the free-acid form of the substrate [1]. |
| Cofactor |
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| History |
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| Reactions |
(25R)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-oyl-CoA + H(2)O + acceptor = (24R,25R)-3-alpha,7-alpha,12-alpha,24-tetrahydroxy-5- beta-cholestan-26-oyl-CoA + reduced acceptor. |
