| 英文名 |
4-hydroxy-2-oxoheptanedioate aldolase |
| Example Structure |
 |
| 别名 |
4-hydroxy-2-oxo-heptane-1,7-dioate aldolase, HpaI, HpcH |
| EC Number |
4.1.2.52 |
| CAS编号 |
|
| Comments |
Requires Co2+?or Mn2+?for activity. The enzyme is also able to catalyse the aldol cleavage of 4-hydroxy-2-oxopentanoate and 4-hydroxy-2-oxohexanoate, and can use 2-oxobutanoate as carbonyl donor, with lower efficiency. In the reverse direction, is able to condense a range of aldehyde acceptors with pyruvate. The enzyme from the bacterium?Escherichia coli?produces a racemic mixture of (4R)- and (4S)-hydroxy-2-oxoheptanedioate [4]. |
| Cofactor |
cobalt cation?or?Mn2+ |
| History |
|
| Reactions |
4-hydroxy-2-oxoheptanedioate = pyruvate + succinate semialdehyde. |
