| 英文名 |
(4-hydroxyphenyl)alkanoate synthase |
| Example Structure |
 |
| 别名 |
4-hydroxyphenylalkanoate synthase, msl7, PKS1, Pks15, Pks15/1 |
| EC Number |
2.3.1.261 |
| CAS编号 |
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| Comments |
The enzyme is part of the biosynthetic pathway of phenolphthiocerol, a lipid that serves as a virulence factor of pathogenic mycobacteria. It catalyses the elongation of 4-hydroxybenzoate that is loaded on its acyl-carrier domain to form (4-hydroxyphenyl)alkanoate intermediates. The enzyme adds either 8 or 9 malonyl-CoA units, resulting in formation of 17-(4-hydroxyphenyl)heptadecanoate or 19-(4-hydroxyphenyl)nonadecanoate, respectively. As the enzyme lacks a thioesterase domain [1], the product remains loaded on the acyl-carrier domain at the end of catalysis, and has to be hydrolysed by an as-yet unknown mechanism. |
| Cofactor |
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| History |
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| Reactions |
(1) 4-hydroxybenzoyl-[(4-hydroxyphenyl)alkanoate synthase] + 8 malonyl- CoA + 16 Nadph = 17-(4-hydroxyphenyl)heptadecanoyl- [(4-hydroxyphenyl)alkanoate synthase] + 8 CO(2) + 8 CoA + 16 NADP(+) + 8 H(2)O. (2) 4-hydroxybenzoyl-[(4-hydroxyphenyl)alkanoate synthase] + 9 malonyl- CoA + 18 Nadph = 19-(4-hydroxyphenyl)nonadecanoyl- [(4-hydroxyphenyl)alkanoate synthase] + 9 CO(2) + 9 CoA + 18 NADP(+) + 9 H(2)O. |
