| 英文名 |
4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase |
| Example Structure |
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| 别名 |
FA2H, AtFAH1, FA2H, FAH1, fatty acid 2-hydroxylase, fatty acid 2-hydroxylase 1, fatty acid alpha-hydroxylase, SCS7, Scs7p, scScs7p, sphingolipid alpha-hydroxylase |
| EC Number |
1.14.18.6 |
| CAS编号 |
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| Comments |
The enzyme, characterized from yeast and mammals, catalyses the hydroxylation of carbon 2 of long- or very-long-chain fatty acids attached to (4R)-4-hydroxysphinganine during de novo ceramide synthesis. The enzymes from yeast and from mammals contain an N-terminal cytochrome b5 domain that acts as the direct electron donor to the desaturase active site. The newly introduced 2-hydroxyl group has R-configuration. cf. EC 1.14.18.7, dihydroceramide fatty acyl 2-hydroxylase. |
| Cofactor |
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| History |
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| Reactions |
A phytoceramide + 2 ferrocytochrome b5 + O(2) + 2 H(+) = a (2’R)- 2′-hydroxyphytoceramide + 2 ferricytochrome b5 + H(2)O. |
