| 英文名 |
4-phosphoerythronate dehydrogenase |
| Example Structure |
 |
| 别名 |
4-O-phosphoerythronate dehydrogenase, D-erythronate-4-phosphate dehydrogenase, erythronate-4-phosphate dehydrogenase, More, pdx gene product, PDXB, PdxB 4PE dehydrogenase, RdxB |
| EC Number |
1.1.1.290 |
| CAS编号 |
|
| Comments |
This enzyme catalyses a step in a bacterial pathway for the biosynthesis of pyridoxal 5′-phosphate. The enzyme contains a tightly-bound NAD(H) cofactor that is not re-oxidized by free NAD+. In order to re-oxidize the cofactor and restore enzyme activity, the enzyme catalyses the reduction of a 2-oxo acid (such as 2-oxoglutarate, oxaloacetate, or pyruvate) to the respective (R)-hydroxy acid [6]. cf. EC 1.1.1.399, 2-oxoglutarate reductase. |
| Cofactor |
NAD+ |
| History |
|
| Reactions |
4-phospho-D-erythronate + NAD(+) = (3R)-3-hydroxy-2-oxo-4- phosphonooxybutanoate + Nadh. |
