| 英文名 |
5-hydroxyfuranocoumarin 5-O-methyltransferase |
| Example Structure |
 |
| 别名 |
bergaptol-5-O-methyltransferase, BMT, furanocoumarin 5-methyltransferase, furanocoumarin 5-O-methyltransferase, methyltransferase, bergaptol |
| EC Number |
2.1.1.69 |
| CAS编号 |
67339-12-2 |
| Comments |
Converts bergaptol into bergapten, which has therapeutic potential in the treatment of psoriasis as it has photosensitizing and antiproliferative activities [4]. The enzyme methylates the 5-hydroxy group of some hydroxy- and methylcoumarins, such as 5-hydroxyxanthotoxin, but has little activity on non-coumarin phenols [1]. Caffeate, 5-hydroxyferulate and daphnetin are not substrates [4]. Cu2+, Zn2+ and Co2+ cause enzyme inhibition [4]. (see also EC 2.1.1.70, 8-hydroxyfuranocoumarin 8-O-methyltransferase). |
| Cofactor |
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| History |
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| Reactions |
(1) S-adenosyl-L-methionine + a 5-hydroxyfurocoumarin = S-adenosyl-L- homocysteine + a 5-methoxyfurocoumarin. (2) S-adenosyl-L-methionine + bergaptol = S-adenosyl-L-homocysteine + bergapten. |
