| 英文名 |
7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase |
| Example Structure |
 |
| 别名 |
7alpha-hydroxy-4-cholest-3-on3 12alpha-monooxygenase, 7alpha-hydroxy-4-cholesten-3-one 12alpha-monooxygenase, CYP12, CYP8B1, HCO 12alpha-hydroxylase, sterol 12alpha-hydroxylase |
| EC Number |
1.14.18.8 |
| CAS编号 |
|
| Comments |
A P-450 heme-thiolate protein. Requires EC 1.6.2.4, NADPH¡ªhemoprotein reductase and cytochrome b5 for maximal activity. This enzyme is important in bile acid biosynthesis, being responsible for the balance between the formation of cholic acid and chenodeoxycholic acid [2]. |
| Cofactor |
heme-thiolate |
| History |
|
| Reactions |
7-alpha-hydroxycholest-4-en-3-one + 2 ferrocytochrome b5 + 2 H(+) + O(2) = 7-alpha,12-alpha-dihydroxycholest-4-en-3-one + 2 ferricytochrome b5 + + H(2)O. |
