| 英文名 |
8-hydroxyfuranocoumarin 8-O-methyltransferase |
| Example Structure |
 |
| 别名 |
furanocoumarin 8-methyltransferase, furanocoumarin 8-O-methyl-transferase, methyltransferase, xanthotoxol, XMT |
| EC Number |
2.1.1.70 |
| CAS编号 |
67339-13-3 |
| Comments |
Converts xanthotoxol into xanthotoxin, which has therapeutic potential in the treatment of psoriasis as it has photosensitizing and antiproliferative activities [4]. Methylates the 8-hydroxy group of some hydroxy- and methylcoumarins, but has little activity on non-coumarin phenols. (see also EC 2.1.1.69, 5-hydroxyfuranocoumarin 5-O-methyltransferase). |
| Cofactor |
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| History |
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| Reactions |
(1) S-adenosyl-L-methionine + an 8-hydroxyfurocoumarin = S-adenosyl-L- homocysteine + an 8-methoxyfurocoumarin. (2) S-adenosyl-L-methionine + xanthotoxol = S-adenosyl-L-homocysteine + xanthotoxin. |
