| 英文名 |
9,12-octadecadienoate 8-hydroperoxide 8R-isomerase |
| Example Structure |
 |
| 别名 |
5,8-LDS, 5,8-linoleate diol synthase, 5,8-linoleate diol synthases, PpoA |
| EC Number |
5.4.4.5 |
| CAS编号 |
|
| Comments |
The enzyme contains heme [3]. The bifunctional enzyme from?Aspergillus nidulans?uses different heme domains to catalyse two separate reactions. Linoleic acid is oxidized within the N-terminal heme peroxidase domain to (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate (cf. EC?1.13.11.60, linoleate 8R-lipoxygenase), which is subsequently isomerized to (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate within the C-terminal P450 heme thiolate domain [3]. |
| Cofactor |
heme |
| History |
|
| Reactions |
(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate = (5S,8R,9Z,12Z)-5,8- dihydroxyoctadeca-9,12-dienoate. |
