| 英文名 |
acyl-lipid (11-3)-desaturase |
| Example Structure |
 |
| 别名 |
AtSLD1, AtSLD2, Boofd8, Ca-SLDp, D8A, DELTA6-desaturase, DELTA8 acyl-CoA-dependent desaturase, DELTA8 desaturase, DELTA8 sphingobase desaturase, Delta8 sphingolipid desaturase, DELTA8-desaturase, DELTA8-fatty-acid desaturase, DELTA8-sphingolipid desaturase, FADS2, SLD, SlSLD, sphingolipid delta8 desaturase, sphingolipid DELTA8 LCB desaturase, sphingolipid DELTA8 long-chain base desaturase, sphingolipid DELTA8-desaturase, TpdesB |
| EC Number |
1.14.19.4 |
| CAS编号 |
|
| Comments |
The enzyme, characterized from the protist Euglena gracilis [1] and the microalga Rebecca salina [2], introduces a cis double bond at the 8-position in 20-carbon fatty acids that are incorporated into a glycerolipid and have an existing ¦¤11 desaturation. The enzyme is a front-end desaturase, introducing the new double bond between the pre-existing double bond and the carboxyl-end of the fatty acid. It contains a cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase, and does not require an external cytochrome. Involved in alternative pathways for the biosynthesis of the polyunsaturated fatty acids arachidonate and icosapentaenoate. |
| Cofactor |
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| History |
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| Reactions |
(1) An (11Z,14Z)-icosa-11,14-dienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O(2) + 2 H(+) = an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl- [glycerolipid] + 2 ferricytochrome b5 + 2 H(2)O. (2) An (11Z,14Z,17Z)-icosa-11,14,17-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O(2) + 2 H(+) = an (8Z,11Z,14Z,17Z)-icosa- 8,11,14,17-tetraenoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H(2)O. |
