| 英文名 |
acyl-lipid (8-3)-desaturase |
| Example Structure |
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| 别名 |
acyl-lipid 5-desaturase, AL21, C20 DELTA5cis-desaturase, D5b, D5D, D5des, delta 5 desaturase, DELTA 5 fatty acid desaturase, delta-5 desaturase, DELTA-5-desaturase, DELTA5 desaturase, DELTA5 fatty acid desaturase, DELTA5-Des, DELTA5-desaturase, DELTA5-fatty acid desaturase, DELTA5-fatty-acid desaturase, DES5, desat7, FadA, FadB, FADS1, fads2b, FAT-4, fatty acid desaturase, PPDES5, PsD5Des |
| EC Number |
1.14.19.30 |
| CAS编号 |
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| Comments |
The enzyme, which has been characterized from multiple organisms including the moss Physcomitrella patens, the marine microalga Rebecca salina, and the filamentous fungus Mortierella alpina, introduces a cis double bond at the 5-position in 20-carbon polyunsaturated fatty acids incorporated in a glycerolipid that contain a ¦¤8 double bond. The enzyme contains a cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase, and does not require an external cytochrome. |
| Cofactor |
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| History |
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| Reactions |
(1) An (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O(2) + 2 H(+) = a (5Z,8Z,11Z,14Z)-icosatetra- 5,8,11,14-tetraenoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H(2)O. (2) An (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + 2 ferrocytochrome b5 + O(2) + 2 H(+) = a (5Z,8Z,11Z,14Z,17Z)-icosa- 5,8,11,14,17-pentaenoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H(2)O. |
