| 英文名 |
acyl-lipid omega-(9-4) desaturase |
| Example Structure |
 |
| 别名 |
acyl-lipid 7-desaturase, acyl-lipid omega-13 desaturase, DES, omega13 desaturase |
| EC Number |
1.14.19.12 |
| CAS编号 |
|
| Comments |
The enzyme, characterized from the green alga Chlamydomonas reinhardtii, is a front-end desaturase that introduces a cis double bond in ¦Ø9 unsaturated C18 or C20 fatty acids incorporated into lipids, at a position 4 carbon atoms from the existing ¦Ø9 bond, towards the carboxy end of the fatty acid (at the ¦Ø13 position). When acting on 20:2¦¤(11,14) and 20:3¦¤(11,14,17) substrates it introduces the new double bond between carbons 7 and 8. The enzyme contains a cytochrome b5 domain that acts as the direct electron donor for the active site of the desaturase. |
| Cofactor |
|
| History |
|
| Reactions |
(1) Linoleoyl-[glycerolipid] + 2 ferrocytochrome b5 + O(2) + 2 H(+) = pinolenoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H(2)O. (2) Alpha-linolenoyl-[glycerolipid] + 2 ferrocytochrome b5 + O(2) + 2 H(+) = coniferonoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H(2)O. |
