| 别名 |
3′-phosphoadenosine 5′-phosphosulfate synthetase1, 3′-phosphoadenosine-5′-phosphosulfate synthetase, 5′-phosphoadenosine sulfate kinase, adenosine 5′-phosphosulfate kinase, adenosine 5-phosphosulfate kinase, adenosine 5¡¯-phosphosulfate kinase, adenosine phosphosulfate kinase, adenosine phosphosulfokinase, adenosine-5′-phosphosulfate 3′-phosphotransferase, adenosine-5′-phosphosulfate kinase, adenosine-5′-phosphosulfate-3′-phosphokinase, adenosine-5’phosphosulfate kinase, adenosine-5¡¯-phosphosulfate kinase, adenylyl-sulfate kinase, adenylylsulfate 3′-phosphotransferase, adenylylsulfate kinase, APK, APK1, APK2, APK3, APK4, APS kinase, APS-kinase, APSK, APSK1, ATP adenosine-5′-phosphosulfate 3′-phosphotransferase, ATP sulfurylase-APS kinase, CysC, kinase, adenylylsulfate (phosphorylating), MgATP:APS 3′-phosphotransferase, More, PAPS 2, PAPS synthase, PAPS synthetase, PAPSS, PAPSS 1, PAPSS1 |
| Comments |
The human phosphoadenosine-phosphosulfate synthase (PAPS) system is a bifunctional enzyme (fusion product of two catalytic activities). In a first step, sulfate adenylyltransferase catalyses the formation of adenosine 5′-phosphosulfate (APS) from ATP and inorganic sulfate. The second step is catalysed by the adenylylsulfate kinase portion of 3′-phosphoadenosine 5′-phosphosulfate (PAPS) synthase, which involves the formation of PAPS from enzyme-bound APS and ATP. In contrast, in bacteria, yeast, fungi and plants, the formation of PAPS is carried out by two individual polypeptides, sulfate adenylyltransferase (EC?2.7.7.4) and adenylyl-sulfate kinase (EC?2.7.1.25). |
