| 英文名 |
alcohol dehydrogenase (nicotinoprotein) |
| Example Structure |
 |
| 别名 |
4-nitroso-N, N-dimethylaniline-dependent alcohol dehydrogenase, NDMA-ADH, NDMA-dependent alcohol dehydrogenase, np-ADH |
| EC Number |
1.1.99.36 |
| CAS编号 |
|
| Comments |
Contains Zn2+. Nicotinoprotein alcohol dehydrogenases are unique medium-chain dehydrogenases/reductases (MDR) alcohol dehydrogenases that have a tightly bound NAD+/NADH cofactor that does not dissociate during the catalytic process. Instead, the cofactor is regenerated by a second substrate or electron carrier. While the in vivo electron acceptor is not known, N,N-dimethyl-4-nitrosoaniline (NDMA) can serve this function in vitro. The enzyme from the Gram-positive bacterium Amycolatopsis methanolica can accept many primary alcohols as substrates, including benzylalcohol [1]. |
| Cofactor |
Zn2+ |
| History |
|
| Reactions |
Ethanol + acceptor = acetaldehyde + reduced acceptor. |
