alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase EC#: 2.4.1.201; 凯望编码 (ChemWhat Code): 1377497
| 英文名 | alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
| Example Structure | ![]() |
| 别名 | acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-glycopeptide beta-1,4-, VI, acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-glycopeptide beta-1-4-, VI, GCNT6, GnT VI, GnT-VI, mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, Mgat6, N-acetylglucosaminyltransferase VI, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase VI, UDP-GlcNAc: GlcNAcbeta1-6(GlcNAcbeta1-2)Manalpha1-R [GlcNAc to Man] beta1-4N-acetylglucosaminyltransferase VI, UDP-GlcNAc:GlcNAcbeta1-6(GlcNAcbeta1-2)Manalpha-R (GlcNAc to Man) beta4-GlcNAc-transferase VI, UDP-GlcNAc:GlcNAcbeta1-6(GlcNAcbeta1-2)Manalpha1-R [GlcNAc to Man]beta1-4N-acetylglucosaminyltransferase VI, UDP-N-acetyl-D-glucosamine (GlcNAc):GlcNAcbeta1-6(GlcNAcbeta1-2)-Manalpha1-R[GlcNAc to Man]beta1,4N-acetylglucosaminyltransferase VI, uridine diphosphoacetylglucosamine-glycopeptide beta-1-4-acetylglucosaminyltransferase VI |
| EC Number | 2.4.1.201 |
| CAS编号 | 119699-68-2 |
| Comments | Requires a high concentration of Mn2+ for maximal activity. The enzyme, characterized from hen oviduct membranes, participates in the processing of N-glycans in the Golgi apparatus. It transfers GlcNAc in ¦Â1-4 linkage to a D-mannose residue that already has GlcNAc residues attached at positions 2 and 6 by ¦Â linkages. No homologous enzyme appears to exist in mammals. |
| Cofactor | |
| History | |
| Reactions | UDP-N-acetyl-D-glucosamine + 2,6-bis(N-acetyl-beta-D-glucosaminyl)-alpha- D-mannosyl-R = Udp + 2,4,6-tris(N-acetyl-beta-D-glucosaminyl)-alpha-D- mannosyl-R. |
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