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The enzyme synthesizes a mixture of sesquiterpenoids from (2Z,6Z)-farnesyl diphosphate. Following dephosphorylation of (2Z,6Z)-farnesyl diphosphate, the (2Z,6Z)-farnesyl carbocation is converted to either the (6R)- or the (6S)-bisabolyl cations depending on the stereochemistry of the 6,1 closure. The (6R)-bisabolyl cation will then lead to the formation of (+)-¦Á-santalene (EC?4.2.3.50), while the (6S)-bisabolyl cation will give rise to (+)-endo-¦Â-bergamotene (see EC?4.2.3.53) as well as (?)-endo-¦Á-bergamotene (see EC?4.2.3.54). Small amounts of (?)-epi-¦Â-santalene are also formed from the (6R)-bisabolyl cation and small amounts of (?)-exo-¦Á-bergamotene are formed from the (6S)-bisabolyl cation [1]. |
![Example Structure of (+)-alpha-santalene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing] EC#: 4.2.3.50](/wp-content/uploads/enzyme-structure/4.2.3.50.jpg)