alternative-complement-pathway C3/C5 convertase EC#: 3.4.21.47; 凯望编码 (ChemWhat Code): 1380540

英文名 alternative-complement-pathway C3/C5 convertase
Example Structure Example Structure of alternative-complement-pathway C3/C5 convertase EC#: 3.4.21.47
别名 (C3b)n,Bb, (CVF)-dependent glycine-rich-beta-glucoprotein, alternative C3 convertase, alternative C5 convertase, alternative complement pathway C3 convertase, alternative complement pathway C3(C5) convertase, alternative pathway C3 convertase, alternative pathway C3 convertase complex, alternative pathway C3-convertase, alternative pathway C5 convertase, alternative pathway of complement C3/C5 convertase, alternative-complement-pathway C3/C5 convertase, AP C3-convertase, AP C5 convertase, APC C3/C5 convertase, C3 convertase, C3 proactivator, C3/C5 convertase, C3b,Bb, C3b2, C3bB complex, C3bBb, C3bBb convertase, C3bBb3b, C3bBbC3b, C5 convertase, cobra venom factor-dependent C3 convertase, complement alternative pathway C3 convertase, complement C 3(C 5) convertase (amplification), complement component C3/C5 convertase (alternative), convertase, complement C3(C5) (amplification), CVF,Bb, CVFh,Bb, CVFn,Bb, GBG, Glycine-rich beta glycoprotein, heat-labile factor, PBF2, proenzyme factor B, properdin factor B
EC Number 3.4.21.47
CAS编号 80295-67-6
Comments A bimolecular complex of complement fragment Bb with either C3b or cobra venom factor; Bb contains the active site. Bb is formed by cleavage of proenzyme factor B by factor D. Cleavage of complement component C5 requires additional C3b which binds C5 and renders it susceptible to cleavage by C3b,Bb complex. C3b,Bb is stabilized in plasma by factor P. Complement factor B is in peptidase family?S1?(trypsin family).
Cofactor
History
Reactions Cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha- chain to yield C5a and C5b.

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