AMG-650 CAS#: 2410796-79-9; 凯望编码 (ChemWhat Code): 1417543

IdentificationPhysical DataSpectra
Route of Synthesis (ROS)Safety and HazardsOther Data

Identification

英文名AMG-650
IUPAC Namepyridin-3-amine
分子结构Structure of AMG-650 CAS 2410796-79-9
CAS编号 2410796-79-9
别名Sovilnesib
2410796-79-9
AMG-650
AMG 650 [WHO-DD]
OP393M4H32
UNII-OP393M4H32
AMG 650
Benzamide, 2-(6-azaspiro(2.5)oct-6-yl)-N-(2-(4,4-difluoro-1-piperidinyl)-6-methyl-4-pyrimidinyl)-4-(((2-hydroxyethyl)sulfonyl)amino)-
Sovilnesib(AMG-650)?
CHEMBL5084301
SCHEMBL22119383
KBDGEJDIHZDPHN-UHFFFAOYSA-N
US11236069, Example 4
BDBM535532
EX-A6760
US11236069, Example 15
MFCD34578308
NSC839866
AKOS040757673
NSC-839866
AC-37121
MS-30230
N-[2-(4,4-Difluoro-1-piperidyl)-6-methyl-4-pyrimidinyl]-4-(2-hydroxyethylsulfonamido)-2-(6-azaspiro[2.5]octan-6-yl)benzamide
SY345506
HY-132840
CS-0204143
G18509
2-(6-azaspiro[2.5]octan-6-yl)-N-[2-(4,4-difluoropiperidin-1-yl)-6-methylpyrimidin-4-yl]-4-(2-hydroxyethylsulfonylamino)benzamide
N-(2-(4,4-Difluoropiperidin-1-yl)-6- methylpyrimidin-4-yl)-4-((2- hydroxyethyl)sulfonamido)-2-(6- azaspiro[2.5]octan-6-yl)benzamide
分子式C26H34F2N6O4S
分子量564.6
InChIInChI=1S/C26H34F2N6O4S/c1-18-16-22(31-24(29-18)34-12-8-26(27,28)9-13-34)30-23(36)20-3-2-19(32-39(37,38)15-14-35)17-21(20)33-10-6-25(4-5-25)7-11-33/h2-3,16-17,32,35H,4-15H2,1H3,(H,29,30,31,36)
InChI KeyKBDGEJDIHZDPHN-UHFFFAOYSA-N
Isomeric SMILESCC1=CC(=NC(=N1)N2CCC(CC2)(F)F)NC(=O)C3=C(C=C(C=C3)NS(=O)(=O)CCO)N4CCC5(CC5)CC4

Physical Data

AppearanceSolid

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

GHS Hazard Statements
Not Classified

Other Data

HS Code
StorageStore at -20°C and away from light
Shelf Life2 years
Market Price
Use Pattern
AMG 650 is a highly efficient and selective inhibitor targeting KIF18A, an overexpressed kinesin motor protein in human cancers. It selectively inhibits KIF18A MT-ATPase motor activity, displaying specificity towards various kinesin proteins. At concentrations affecting sensitive tumor cells, AMG 650 has minimal impact on the in vitro proliferation of human bone marrow mononuclear cells (>100 times). In vivo, AMG 650 exhibits low clearance, a long half-life, and favorable oral bioavailability. Additionally, when combined with the PARP inhibitor olaparib, AMG 650 enhances anticancer activity in tumor models with alterations in BRCA1 and CCNE1 compared to single-agent treatment.

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认证生产商

Caming Pharmaceutical Limited http://www.caming.com/
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其他供应商

Watson International Limited 访问Watson官网

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