Amino-PEG8-acid CAS#: 756526-04-2; 凯望编码 (ChemWhat Code): 1162598
Identification
| 英文名 | Amino-PEG8-acid |
| IUPAC Name | 3-[2-[2-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid |
| 分子结构 |  |
| CAS编号 | 756526-04-2 |
| EINECS Number | |
| MDL Number | MFCD11041146 |
| 别名 | Amino-PEG8-Acid 756526-04-2 NH2-PEG8-COOH H2N-PEG8-CH2CH2COOH Amino-PEG8-COOH NH2-PEG9-acid 1-AMINO-3,6,9,12,15,18,21,24-OCTAOXAHEPTACOSAN-27-OIC ACID MFCD11041146 alpha-amine-omega-propionic acid octaethylene glycol Amine-PEG8-COOH H2N-Dpeg(8)-cooh Amino-dPEG(R)8-acid SCHEMBL1578111 DTXSID901200357 27-Amino-4,7,10,13,16,19,22,25-octaoxaheptacosanoic acid ZINC83253934 AKOS030213465 GS-9370 |
| 分子式 | C19H39NO10 |
| 分子量 | 441.5 |
| InChI | InChI=1S/C19H39NO10/c20-2-4-24-6-8-26-10-12-28-14-16-30-18-17-29-15-13-27-11-9-25-7-5-23-3-1-19(21)22/h1-18,20H2,(H,21,22) |
| InChI Key | YLKOHZCQTVYVDB-UHFFFAOYSA-N |
| Canonical SMILES | C(COCCOCCOCCOCCOCCOCCOCCOCCN)C(=O)O |
| Patent Information | ||
| Patent ID | Title | Publication Date |
| US2022/153683 | METHOD FOR PRODUCING HETERO-TYPE MONODISPERSE POLYETHYLENE GLYCOL DERIVATIVE | 2020 |
| CN107235848 | A-amido glycol propionic acid preparation method (by machine translation) | 2017 |
| US2013/296539 | MAGNETIC RESONANCE IMAGING AGENTS FOR CALCIFICATION | 2013 |
Physical Data
| Appearance | Waxy solid |
Spectra
| Description (NMR Spectroscopy) | Nucleus (NMR Spectroscopy) | Solvents (NMR Spectroscopy) | Temperature (NMR Spectroscopy), °C | Frequency (NMR Spectroscopy), MHz |
| Chemical shifts | 1H | CD3OD | ||
| Chemical shifts, Spectrum | 1H | chloroform-d1 | 200 | |
| Chemical shifts, Spectrum | 13C | chloroform-d1 | 50 | |
| Chemical shifts | 1H | chloroform-d1 | 400 |
Route of Synthesis (ROS)
Route of Synthesis (ROS) of Amino-PEG8-acid CAS 756526-04-2
| Conditions | Yield |
| With palladium 10% on activated carbon; hydrogen In ethanol at 20℃; under 750.075 Torr; for 16h; | 93% |
| Experimental Procedure General procedure: To a solution of the appropriate azido compound s10a-c (1 eq.) in absolute ethanol, 10% Pd/C (0.05 eq) wasadded. The suspension was degassed under vacuum and purged with hydrogen three times then stirred at roomtemperature under hydrogen atmosphere (1 bar) for 16 h. The reaction mixture was filtered through a pad ofCelite 545, the filtrate was evaporated under reduced pressure to afford the expected compounds 5a-c whichwas engaged in the next step without further purification. |
Safety and Hazards
| Pictogram(s) |  |
| Signal | Warning |
| GHS Hazard Statements | H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral] H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] |
| Precautionary Statement Codes | P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.) |
Other Data
| Transportation | Under the room temperature and away from light |
| HS Code | |
| Storage | Under the room temperature and away from light |
| Shelf Life | 1 year |
| Market Price |
| Druglikeness | |
| Lipinski rules component | |
| 分子量 | 441.519 |
| logP | -2.546 |
| HBA | 11 |
| HBD | 2 |
| Matching Lipinski Rules | 3 |
| Veber rules component | |
| Polar Surface Area (PSA) | 137.16 |
| Rotatable Bond (RotB) | 26 |
| Matching Veber Rules | 1 |
| Toxicity/Safety Pharmacology |
| Quantitative Results |
| Use Pattern |
| Amino-PEG8-acid CAS#: 756526-04-2 is a polyethylene glycol (PEG) linker to facilitate antibody-drug conjugate (ADC) development projects. |
试剂采购 | |
| 没有试剂厂商? | 向凯望发送快速询价 |
| 想要被列为试剂厂商? (付费服务) | 点击这里联系凯望 |
认证生产商 | |
| Caming Pharmaceutical Limited | http://www.caming.com/ |
| 想要被列为认证生产商 (需要通过认证)? | 请下载并填写 这份表格并发邮件到approved-manufacturers@chemwhat.com |
其他供应商 | |
| Watson International Limited | 访问Watson官网 |
如需其他帮助，请联系我们 | |
| 联系我们获取其它信息或服务 | 点击这里联系凯望 |