Amlexanox CAS#: 68302-57-8; 凯望编码 (ChemWhat Code): 1370374
Identification
| 英文名 | Amlexanox |
| IUPAC Name | 2-amino-5-oxo-7-propan-2-ylchromeno[2,3-b]pyridine-3-carboxylic acid |
| 分子结构 |  |
| CAS编号 | 68302-57-8 |
| 别名 | amlexanox, 2-amino-7-isopropyl-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid, Amlexanox, 2-amino-7-(1-methylethyl)-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid, 2-amino-7-isopropyl-5-oxo-5H-[1]benzopyrano[2,3-b]pyridin-3-carboxylic acid, 2-amino-7-isopropyl-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid, 2-amino-5-oxo-7-propan-2-ylchromeno[2,3-b]pyridine-3-carboxylic acid |
| 分子式 | C16H14N2O4 |
| 分子量 | 298.298 |
| InChI | InChI=1S/C16H14N2O4/c1-7(2)8-3-4-12-9(5-8)13(19)10-6-11(16(20)21)14(17)18-15(10)22-12/h3-7H,1-2H3,(H2,17,18)(H,20,21) |
| InChI Key | SGRYPYWGNKJSDL-UHFFFAOYSA-N |
| Canonical SMILES | CC(C)C1=CC2=C(C=C1)OC3=NC(=C(C=C3C2=O)C(=O)O)N |
| Patent Information | ||
| Patent ID | Title | Publication Date |
| US2007/135473 | Method of treating tumors with azaxanthones | 2007 |
Physical Data
| Appearance | Off-white to light yellow crystal or powder |
| Melting Point | 300°C min |
| Partition octan-1-ol/water (MCS) – 3 |
| log POW |
| 3.48 |
| 2.76 |
| 3.08 |
| log POW | Temperature (Partition octan-1-ol/water (MCS)), °C | pH |
| 3.41 | ||
| 2 | ||
| 2.4 | 25 | ~ 7.4 |
Spectra
| Description (NMR Spectroscopy) | Nucleus (NMR Spectroscopy) | Solvents (NMR Spectroscopy) |
| Chemical shifts, Spectrum | 1H | dimethylsulfoxide-d6 |
Route of Synthesis (ROS)
| Conditions | Yield |
| With sulfuric acid; acetic acid at 130℃ for 3h | 88% |
Safety and Hazards
| Pictogram(s) |  |
| Signal | Warning |
| GHS Hazard Statements | H302: Harmful if swallowed [Warning Acute toxicity, oral] Information may vary between notifications depending on impurities, additives, and other factors. |
| Precautionary Statement Codes | P264, P270, P301+P312, P330, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.) |
Other Data
| Transportation | Not dangerous goods |
| Under the room temperature and away from light | |
| HS Code | 294200 |
| Storage | Under the room temperature and away from light |
| Market Price | USD 1343/kg |
| Use Pattern |
| Amlexanox is an anti-allergic drug with anti-inflammatory properties. |
| Amlexanox is an anti-allergy and anti-asthma drug that blocks histamine and leukotriene release from leukocytes and mast cells. Amlexanox has also been shown to inhibit cahaperone activity of Hsp90, and S100A13, which is involved in transport of proteins devoid of signal peptide sequences. |
| KRAS WT cancer or a cancer of a KRAS mutant cell line with wild-type PI3K |
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认证生产商 | |
| Caming Pharmaceutical Ltd | http://www.caming.com/ |
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其他供应商 | |
| Watson International Limited | 访问Watson官网 |
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