| 英文名 |
amorpha-4,11-diene synthase |
| Example Structure |
 |
| 别名 |
ADS, ADS1, ADS3963, amorpha-4,11-diene synthase, amorphadiene synthase, AMS |
| EC Number |
4.2.3.24 |
| CAS编号 |
|
| Comments |
Requires Mg2+?and Mn2+?for activity. This is a key enzyme in the biosynthesis of the antimalarial endoperoxide artemisinin [3]. Catalyses the formation of both olefinic [e.g. amorpha-4,11-diene, amorpha-4,7(11)-diene, ¦Ã-humulene and ¦Â-sesquiphellandrene] and oxygenated (e.g. amorpha-4-en-7-ol) sesquiterpenes, with amorpha-4,11-diene being the major product. When geranyl diphosphate is used as a substrate, no monoterpenes are produced [2]. |
| Cofactor |
Mn2+
Mg2+ |
| History |
|
| Reactions |
(2E,6E)-farnesyl diphosphate = amorpha-4,11-diene + diphosphate. |
