| 英文名 |
anthrax lethal factor endopeptidase |
| Example Structure |
 |
| 别名 |
anthrax lethal factor, anthrax lethal factor protease, anthrax lethal toxin, anthrax LF, Bacillus anthracis lethal toxin, lethal factor, lethal factor of anthrax toxin, lethal toxin, LeTx, LF, LTx |
| EC Number |
3.4.24.83 |
| CAS编号 |
|
| Comments |
From the bacterium?Bacilus anthracis?that causes anthrax. One of three proteins that are collectively termed anthrax toxin. Cleaves several MAP kinase kinases near their N-termini, preventing them from phosphorylating the downstream mitogen-activated protein kinases. In peptidase family?M34. |
| Cofactor |
Zn2+ |
| History |
|
| Reactions |
Preferred amino acids around the cleavage site can be denoted BBBBxHx-|-H, in which B denotes Arg or Lys, h denotes a hydrophobic amino acid, and x is any amino acid. The only known protein substrates are mitogen-activated protein (MAP) kinase kinases. |
