| 英文名 |
aromatase |
| Example Structure |
 |
| 别名 |
Cyp19a, CYP19A1, Cyp19a1a, Cyp19a1b, Cyp19A3, cytochrome P450 aromatase, P450arom |
| EC Number |
1.14.14.14 |
| CAS编号 |
|
| Comments |
A cytochrome P450. The enzyme catalyses three sequential hydroxylations of the androgens androst-4-ene-3,17-dione and testosterone, resulting in their aromatization and forming the estrogens estrone and 17¦Â-estradiol, respectively. |
| Cofactor |
|
| History |
|
| Reactions |
(1) Testosterone + 3 [reduced NADPH–hemoprotein reductase] + 3 O(2) = 17-beta-estradiol + formate + 4 H(2)O + 3 [oxidized NADPH–hemoprotein reductase]. (2) Androst-4-ene-3,17-dione + 3 [reduced NADPH–hemoprotein reductase] + 3 O(2) = estrone + formate + 4 H(2)O + 3 [oxidized NADPH–hemoprotein reductase]. |
