| 英文名 |
ATP-dependent NAD(P)H-hydrate dehydratase |
| Example Structure |
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| 别名 |
(S)-NAD(P)HX dehydratase, ADP-dependent (S)-NAD(P)H-hydrate dehydratase, ADP/ATP-dependent NAD(P)H-hydrate dehydratase, At5g19150, ATP-dependent H4NAD(P)OH dehydratase, ATP-dependent NNRD, BSU38720, Carkd, More, NAD(P)H-hydrate dehydratase, NAD(P)HX dehydratase, NAD(P)X dehydratase, NAXD, NNRD, reduced nicotinamide adenine dinucleotide hydrate dehydratase, YKL151C, YxkO |
| EC Number |
4.2.1.93 |
| CAS编号 |
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| Comments |
Acts equally well on hydrated NADH and hydrated NADPH. NAD(P)H spontaneously hydrates to both the (6S)- and (6R)- isomers, and these are interconverted by EC?5.1.99.6, NAD(P)H-hydrate epimerase, to a 60:40 ratio [4]. Hence EC?4.2.1.93?together with EC?5.1.99.6?can restore the mixture of hydrates into NAD(P)H [3,4]. The enzyme from eukaryotes has no activity with ADP, contrary to the enzyme from bacteria (cf. EC?4.2.1.136, ADP-dependent NAD(P)H-hydrate dehydratase) [4]. |
| Cofactor |
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| History |
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| Reactions |
(1) Atp + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide = Adp + phosphate + nadh. (2) Atp + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate = Adp + phosphate + nadph. |
