| 英文名 |
atrolysin A |
| Example Structure |
 |
| 别名 |
Cam-dis, CaVMP-II, crotalus atrox alpha-proteinase, crotalus atrox metalloproteinase, crotalus atrox proteinase, crotalus atrox.alpha.-proteinase, hemorrhagic toxin a, proteinase, Crotalus atrox, zinc metalloproteinase-disintegrin VMP-II |
| EC Number |
3.4.24.1 |
| CAS编号 |
37288-82-7 |
| Comments |
A hemorrhagic endopeptidase of 68 kDa, one of six hemorrhagic toxins in the venom of western diamondback rattlesnake. The 60 kDa hemorrhagic toxin 1 of?Crotalus ruber ruber?shows identical specificity [2]. In peptidase family?M12?(astacin family). Related metalloendopeptidases from rattlesnake venoms are EC?3.4.24.41?(atrolysin B), EC?3.4.24.42?(atrolysin C), EC?3.4.24.43?(atroxase), EC?3.4.24.44?(atrolysin E), EC?3.4.24.45?(atrolysin F), EC?3.4.24.46?(adamalysin), EC?3.4.24.47?(horrilysin), and EC?3.4.24.48?(ruberlysin). |
| Cofactor |
Zn2+ |
| History |
|
| Reactions |
Cleavage of 3-Asn-|-Gln-4, 5-His-|-Leu-6, 10-His-|-Leu-11, 14-Ala-|-Leu- 15 and 16-Tyr-|-Leu-17 in insulin B chain; removes C-terminal Leu from small peptides. |
