| 英文名 |
atrolysin C |
| Example Structure |
 |
| 别名 |
aggrecanase, atrolysin, Crotalus atrox metalloendopeptidase c, hemorrhagic metalloproteinase HT-d, Hemorrhagic toxin c and d, PI metalloproteinase, Ruberlysin |
| EC Number |
3.4.24.42 |
| CAS编号 |
158886-17-0 |
| Comments |
A 24 kDa hemorrhagic endopeptidase from the venom of the western diamondback rattlesnake (Crotalus atrox) that digests type IV collagen, and exists as two forms, c and d. Phosphoramidon inhibits in the 0.1 mM range. In peptidase family?M12?(astacin family). Hemorrhagic toxin-2 of?C. ruber ruber?has the same?Mr and specificity and is a homologue [4,6]. |
| Cofactor |
Zn2+ |
| History |
|
| Reactions |
Cleavage of 5-His-|-Leu-6, 10-His-|-Leu-11, 14-Ala-|-Leu-15, 16-Tyr-|-Leu-17 and 23-Gly-|-Phe-24 of insulin B chain. With small molecule substrates prefers hydrophobic residue at P2′ and small residue such as Ala, Gly at P1. |
