| 英文名 |
atrolysin E |
| Example Structure |
 |
| 别名 |
atrolysin E/D, Crotalus atrox metalloendopeptidase e, Hemorrhagic toxin e, HT-e |
| EC Number |
3.4.24.44 |
| CAS编号 |
172306-51-3 |
| Comments |
A 25.7 kDa hemorrhagic endopeptidase from the venom of the western diamondback rattlesnake (Crotalus atrox) that digests basement membrane components, including the triple helix of type IV collagen. Such action is believed to contribute to the hemorrhagic property by weakening capillary walls. In peptidase family?M12?(astacin family). |
| Cofactor |
Zn2+ |
| History |
|
| Reactions |
Cleavage of 3-Asn-|-Gln-4, 9-Ser-|-His-10 and 14-Ala-|-Leu-15 bonds in insulin B chain and 14-Tyr-|-Gln-15 and 8-Thr-|-Ser-9 in a chain. Cleaves type Iv collagen at 73-Ala-|-Gln-74 in alpha-1-(IV) and at 7-Gly-|-Leu-8 in alpha-2-(IV). |
